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In vitro characterization of multidrug-resistant influenza A(H1N1)pdm09 viruses carrying a dual amino acid substitution associated with reduced susceptibility to neuraminidase inhibitors

التفاصيل البيبلوغرافية
العنوان:	In vitro characterization of multidrug-resistant influenza A(H1N1)pdm09 viruses carrying a dual amino acid substitution associated with reduced susceptibility to neuraminidase inhibitors
المؤلفون:	Noriko Kishida, Hironori Sato, Shinji Watanabe, Kazuya Nakamura, Takato Odagiri, Masayuki Shirakura, Takeshi Shimomura, Yuji Sato, Ikuko Doi, Yukie Shimazu, Shinichi Takao, Emi Takashita, Seiichiro Fujisaki, Masaru Yokoyama, Takuo Ito, Tomoko Kuwahara
بيانات النشر:	Cold Spring Harbor Laboratory, 2018.
سنة النشر:	2018
مصطلحات موضوعية:	Oseltamivir, biology, Chemistry, viruses, virus diseases, Virology, Virus, In vitro, respiratory tract diseases, Multiple drug resistance, chemistry.chemical_compound, Reduced susceptibility, Zanamivir, medicine, biology.protein, Peramivir, Neuraminidase, medicine.drug
الوصف:	We detected influenza A(H1N1)pdm09 viruses carrying dual H275Y/I223R, H275Y/I223K, or H275Y/G147R substitutions in their neuraminidase protein, respectively. These viruses showed cross-resistance to oseltamivir and peramivir and reduced susceptibility to zanamivir. The H275Y/G147R virus retained its replication capability at least in vitro, but the H275Y/I223R and H275Y/I223K viruses did not.
اللغة:	English
DOI:	10.1101/334185
URL الوصول:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754af3e1168a6a708a5f96785fc90229
حقوق:	OPEN
رقم الأكسشن:	edsair.doi.dedup.....754af3e1168a6a708a5f96785fc90229
قاعدة البيانات:	OpenAIRE

الوصف
DOI:	10.1101/334185