Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss
| العنوان: | Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss |
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| المؤلفون: | Marcel G. W. Dijkgraaf, Carla A. Wijbrandts, B L F van Eck-Smit, Paul P. Tak, Danielle M. Gerlag, Ruth Klaasen |
| المساهمون: | Clinical Immunology and Rheumatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Amsterdam Public Health, Epidemiology and Data Science, AII - Amsterdam institute for Infection and Immunity, ACS - Amsterdam Cardiovascular Sciences, Nuclear Medicine, Faculteit der Geneeskunde |
| المصدر: | Annals of the rheumatic diseases, 68(3), 373-376. BMJ Publishing Group Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, 68(3), 373-376. BMJ Publishing Group |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Time Factors, Bone density, Immunology, Osteoporosis, Urology, Arthritis, Antibodies, Monoclonal, Humanized, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, Arthritis, Rheumatoid, Rheumatology, Bone Density, medicine, Adalimumab, Immunology and Allergy, Humans, Prospective Studies, Glucocorticoids, Femoral neck, Aged, Bone mineral, Lumbar Vertebrae, business.industry, Femur Neck, Tumor Necrosis Factor-alpha, Antibodies, Monoclonal, Clinical and Epidemiological Research, Middle Aged, medicine.disease, musculoskeletal system, Surgery, Osteopenia, medicine.anatomical_structure, C-Reactive Protein, Methotrexate, Rheumatoid arthritis, Antirheumatic Agents, Prednisone, Drug Therapy, Combination, Female, business, medicine.drug |
| الوصف: | Objective:To explore the effects of anti-tumour necrosis factor (TNF)α antibody therapy on bone mineral density (BMD) of the lumbar spine and femur neck in patients with rheumatoid arthritis (RA).Methods:A total of 50 patients with active RA (DAS28⩾3.2) who started adalimumab (40 mg subcutaneously/2 weeks) were included in an open label prospective study. All patients used stable methotrexate and were allowed to use prednisone (⩽10 mg/day). The BMD of the lumbar spine and femur neck was measured before and 1 year after start of treatment.Results:Disease activity at baseline (28-joint Disease Activity Score (DAS28)) and disease duration were inversely correlated with femoral neck BMD and lumbar spine BMD (pConclusion:In contrast to the progressive bone loss observed after conventional disease-modifying antirheumatic drug therapy, TNF blockade may result in an arrest of general bone loss. Consistent with previous observations, the data also suggest that the net effect of low-dose corticosteroids on BMD in RA may be beneficial, possibly resulting from their anti-inflammatory effects. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0003-4967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775ddff295150279f40ebfbef14a08a6 https://doi.org/10.1136/ard.2008.091611 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....775ddff295150279f40ebfbef14a08a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00034967 |
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