Total methylated arginine load as a risk parameter in subjects with masked hypertension
| العنوان: | Total methylated arginine load as a risk parameter in subjects with masked hypertension |
|---|---|
| المؤلفون: | Duygu Eryavuz, Ali Unlu, Sedat Abusoglu, Muserref Hosaf, Gulsum Abusoglu, Kenan Demir, Ahmet Avcı |
| المساهمون: | Selçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Hoşaf, Müşerref, Abuşoğlu, Sedat, Avcı, Ahmet, Demir, Kenan, Ünlü, Ali, Eryavuz, Duygu, Abuşoğlu, Gülsüm |
| بيانات النشر: | TAYLOR & FRANCIS INC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Arginine, Physiology, Symmetric dimethylarginine, 030204 cardiovascular system & hematology, Tandem mass spectrometry, Nitric Oxide, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, tandem mass spectrometry, Internal Medicine, medicine, Humans, 030212 general & internal medicine, masked hypertension, omega-N-Methylarginine, Chemistry, total methylarginine load, blood pressure, Blood Pressure Determination, General Medicine, Middle Aged, Masked Hypertension, Endocrinology, Blood pressure, Hypertension, Female, Biomarkers |
| الوصف: | WOS: 000505789700005 PubMed: 30795691 Asymmetric dimethylarginine, symmetric dimethylarginine, and L-monomethylarginine are originated from the subsequent proteolytic catalysis of methylated arginine residues on different proteins and inhibit the endogenous nitric oxide generation. The changes in total methylarginine load (Asymmetric dimethylarginine plus symmetric dimethylarginine plus L-monomethylarginine) may contribute to hypertension. The aim of this study was to determine serum methylarginine concentrations in patients with masked hypertension and determine the association between these biomarkers and blood pressure measurements. Control group, masked hypertension and hypertension groups consisted of 40 subjects (11 males, 28 females, mean age 48.6 +/- 13.1), 28 subjects (14 males, 14 females, mean age 50.9 +/- 11.0) and 36 subjects (15 males, 21 females, mean age 54.4 +/- 12.3 years), respectively (P= 0.149). Serum total methylarginine load was significantly higher in hypertension group (0.63 +/- 0.23) compared to masked hypertension (0.49 +/- 0.16) and control groups (0.38 +/- 0.13) (P= 0.008 and P< 0.001). While there was no statistically significant difference between healthy control groups [0.147 (0.03-0.29)] and masked hypertension patients [0.144 (0.05-0.42)] for serum symmetric dimethylarginine levels (P= 0.970), it was markedly elevated in hypertension group [0.25 (0.07-0.54)] compared to masked hypertension group [0.14 (0.05-0.42)] (P= 0.001). Serum total methylarginine load was positively correlated with night-time SBP (r = 0.214, P= 0.029). Serum methylarginine levels might be a useful marker for determining the courses of clinical hypertension. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77685ee8a95cf4a1c3ce974de735244e https://hdl.handle.net/20.500.12395/38623 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....77685ee8a95cf4a1c3ce974de735244e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |