Familial risk for psychiatric disorders in military veterans who have post-traumatic stress disorder with psychosis
العنوان: | Familial risk for psychiatric disorders in military veterans who have post-traumatic stress disorder with psychosis |
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المؤلفون: | Aengus OConghaile, Lynn E. DeLisi, Diane L Smedberg, Ah L Shin |
المصدر: | Psychiatric Genetics. 28:24-30 |
بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
سنة النشر: | 2018 |
مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Psychosis, behavioral disciplines and activities, Stress Disorders, Post-Traumatic, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Genetics, medicine, Humans, Bipolar disorder, Medical History Taking, Psychiatry, Biological Psychiatry, Genetics (clinical), Depression (differential diagnoses), Aged, Retrospective Studies, Veterans, Aged, 80 and over, Depressive Disorder, business.industry, Traumatic stress, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Anxiety Disorders, 030227 psychiatry, Psychiatry and Mental health, Military Personnel, Psychotic Disorders, Schizophrenia, Anxiety, Female, medicine.symptom, business, 030217 neurology & neurosurgery |
الوصف: | Aims/objectives/background Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. Methods Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder. PTSD with psychotic features was defined as the presence of hallucinations, paranoia, other delusions, thought insertion, withdrawal, broadcasting, and/or dissociative episodes. Results Overall, 22.9% of individuals with PTSD had psychotic symptoms. Having a first-degree relative with bipolar affective and with anxiety disorders was associated with an increased risk of PTSD with psychosis (odds ratio=2.01, 95% confidence interval: 1.01-4.45 and odds ratio=2.72, 95% confidence interval: 1.16-6.41, respectively). A family history of schizophrenia or depression was not associated with risk of developing psychotic features in patients with PTSD. In veterans with military-related PTSD, a familial vulnerability for bipolar disorder and anxiety disorders was associated with an increased risk of developing PTSD with psychotic features. These are preliminary data, given the limitations of a retrospective record review design. These results await replication in future prospective direct family interview studies. |
تدمد: | 0955-8829 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eace70b1567e9b545d019b3f25c9e2 https://doi.org/10.1097/ypg.0000000000000192 |
رقم الأكسشن: | edsair.doi.dedup.....79eace70b1567e9b545d019b3f25c9e2 |
قاعدة البيانات: | OpenAIRE |
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