Protective Effect of an Exopolysaccharide Produced by Lactiplantibacillus plantarum BGAN8 Against Cadmium-Induced Toxicity in Caco-2 Cells
| العنوان: | Protective Effect of an Exopolysaccharide Produced by Lactiplantibacillus plantarum BGAN8 Against Cadmium-Induced Toxicity in Caco-2 Cells |
|---|---|
| المؤلفون: | Svetlana Soković Bajić, Emilija Brdarić, Slađana Đurđić, Jelena Đokić, Milica Živković, Nataša Golić, Magdalena Stevanović, Miroslav Dinić, Patricia Ruas-Madiedo, Maja Tolinacki, Jelena Mutić |
| المساهمون: | Ministry of Education, Science and Technological Development (Serbia) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname Frontiers in Microbiology Frontiers in Microbiology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), cadmium, Lactiplantibacillus plantarum, Metal ions in aqueous solution, chemistry.chemical_element, Inflammation, medicine.disease_cause, Cell junction, Microbiology, Cadmium, exopolysaccharides, 03 medical and health sciences, medicine, oxidative stress, cellular junctions, Cell damage, 030304 developmental biology, Original Research, Cellular junctions, 0303 health sciences, Cadmium, 030306 microbiology, Chemistry, exopolysaccharides, medicine.disease, QR1-502, 3. Good health, Biochemistry, Caco-2, inflammation, Oxidative stress, Toxicity, intestinal epithelial cells, medicine.symptom, Intestinal epithelial cells |
| الوصف: | Cadmium (Cd) ranks seventh on the list of most significant potential threats to human health based on its suspected toxicity and the possibility of exposure to it. It has been reported that some bacterial exopolysaccharides (EPSs) have the ability to bind heavy metal ions. We therefore investigated the capacity of eight EPS-producing lactobacilli to adsorb Cd in the present study, and Lactiplantibacillus plantarum BGAN8 was chosen as the best candidate. In addition, we demonstrate that an EPS derived from BGAN8 (EPS-AN8) exhibits a high Cd-binding capacity and prevents Cd-mediated toxicity in intestinal epithelial Caco-2 cells. Simultaneous use of EPS-AN8 with Cd treatment prevents inflammation, disruption of tight-junction proteins, and oxidative stress. Our results indicate that the EPS in question has a strong potential to be used as a postbiotic in combatting the adverse effects of Cd. Moreover, we show that higher concentrations of EPS-AN8 can alleviate Cd-induced cell damage. This work was funded by the Ministry of Education, Science, and Technological Development of the Republic of Serbia (Registration No. 451-03-9/2021-14/200042) in an agreement on the implementation and financing of research work in 2021. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af4a10874af48db7e171afe4f70e0f5 http://hdl.handle.net/10261/263304 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7af4a10874af48db7e171afe4f70e0f5 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |