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MR features based on LI-RADS identify cytokeratin 19 status of hepatocellular carcinomas

التفاصيل البيبلوغرافية
العنوان: MR features based on LI-RADS identify cytokeratin 19 status of hepatocellular carcinomas
المؤلفون: Li Yang, Sheng-Xiang Rao, Yuan Ji, Wen-Tao Wang, Mengsu Zeng, Xin-Xing Hu, Ying Ding, Zhao-Xia Yang, He-Yue Liang
المصدر: European Journal of Radiology. 113:7-14
بيانات النشر: Elsevier BV, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Logistic regression, Gastroenterology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Cytokeratin, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, Humans, Medicine, Radiology, Nuclear Medicine and imaging, neoplasms, Aged, Retrospective Studies, Liver imaging, Keratin-19, medicine.diagnostic_test, business.industry, Liver Neoplasms, Magnetic resonance imaging, General Medicine, Odds ratio, Middle Aged, HCCS, medicine.disease, Magnetic Resonance Imaging, Mr imaging, digestive system diseases, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, business
الوصف: To retrospectively evaluate the value of MR features based on Liver Imaging Reporting and Data System (LI-RADS ver.2017) for identifying the status of cytokeratin (CK) 19 expression of HCC before surgery.A total of 201 patients with 207 HCCs who underwent MR imaging were reviewed retrospectively. MR features based on LI-RADS ver.2017 as well as clinical data were compared between CK19-positive (n = 51) and CK19-negative (n = 156) HCCs groups. Potential predictive parameters were identified by univariate and multivariate logistic regression analysis and diagnostic odds ratios (ORs) were recorded.MR features including targetoid appearance (p = 0.001) was more frequently observed while non-peripheral "washout" (p 0.0001) and non-rim arterial phase hyper-enhancement (p 0.0001) were found less frequently in CK19-positive HCCs compared to CK19-negative HCCs. At multivariate analysis, serum alphafetoprotein (AFP)20 ng/ml (OR = 5.9) and targetoid appearance (OR = 4.2) and non-peripheral "washout" (OR = 0.2) were significant independent predictors of CK19-positive HCCs.Targetoid appearance and absence non-peripheral "washout" combined with elevated AFP were useful for differentiating CK19-positive HCCs from CK19-negative HCC.
تدمد: 0720-048X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b403d6988f5bee107b1d08775fa3443
https://doi.org/10.1016/j.ejrad.2019.01.036
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....7b403d6988f5bee107b1d08775fa3443
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0720048X