COVID-19–induced acute kidney injury in critically ill patients: epidemiology, risk factors, and outcome
| العنوان: | COVID-19–induced acute kidney injury in critically ill patients: epidemiology, risk factors, and outcome |
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| المؤلفون: | Oussama Benjima, Salah Ben Lakhal, Cyrine Abdennebi, Foued Daly, Sami Abdellatif, Fatma Cherif, Adel Ammous, Yosri Masseoudi, Ahlem Trifi, Yosr Touil, Eya Seghir, Asma Mehdi, Bedis Jeribi |
| المصدر: | Acute and Critical Care. 36:308-316 |
| بيانات النشر: | The Korean Society of Critical Care Medicine, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Mechanical ventilation, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Critically ill, medicine.medical_treatment, Acute kidney injury, Critical Care and Intensive Care Medicine, Critical Care Nursing, medicine.disease, Outcome (game theory), Epidemiology, medicine, Intensive care medicine, business |
| الوصف: | Background: The kidney represents a potential target for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute kidney injury (AKI) can occur through several mechanisms and includes intrinsic tissue injury by direct viral invasion. Clinical data about the clinical course of AKI are lacking. We aimed to investigate the proportion, risk factors, and prognosis of AKI in critical patients affected with coronavirus disease 2019 (COVID-19).Methods: A case/control study conducted in two intensive care units of a tertiary teaching hospital from September to December 2020.Results: Among 109 patients, 75 were male (69%), and the median age was 64 years (interquartile range [IQR], 57–71 years); 48 (44%) developed AKI within 4 days (IQR, 1–9). Of these 48 patients, 11 (23%), 9 (19%), and 28 (58%) were classified as stage 1, 2, and 3, respectively. Eight patients received renal replacement therapy. AKI patients were older and had more frequent sepsis, acute respiratory distress syndrome, and rhabdomyolysis; higher initial urea and creatinine; more marked inflammatory syndrome and hematological disorders; and required more frequent mechanical ventilation and vasopressors. An elevated level of D-dimers (odds ratio [OR], 12.83; 95% confidence interval [CI], 1.9–85) was an independent factor of AKI. Sepsis was near to significance (OR, 5.22; 95% CI, 0.94–28; P=0.058). Renal recovery was identified in three patients. AKI, hypoxemia with the ratio of the arterial partial pressure of oxygen and the inspiratory concentration of oxygen |
| تدمد: | 2586-6060 2586-6052 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf752f62e1741542923c73b97086e0f https://doi.org/10.4266/acc.2021.00934 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7bf752f62e1741542923c73b97086e0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25866060 25866052 |
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