Solid-State Quantification of Cocrystals in Pharmaceutical Tablets Using Transmission Low-Frequency Raman Spectroscopy
| العنوان: | Solid-State Quantification of Cocrystals in Pharmaceutical Tablets Using Transmission Low-Frequency Raman Spectroscopy |
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| المؤلفون: | Takumi Osada, Anjan Roy, Hiroshi Hisada, Toshiro Fukami, James Carriere, Motoki Inoue, Randy Heyler, Tatsuo Koide |
| المصدر: | Analytical Chemistry. 91:13427-13432 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Molecular Structure, Chemistry, Calibration curve, 010401 analytical chemistry, Crystalline materials, Solid-state, Analytical chemistry, Low frequency, Raw material, Spectrum Analysis, Raman, 010402 general chemistry, 01 natural sciences, Cocrystal, 0104 chemical sciences, Analytical Chemistry, law.invention, Glutarates, symbols.namesake, law, Caffeine, symbols, Crystallization, Raman spectroscopy, Tablets |
| الوصف: | To enable the continuous production of cocrystal-containing pharmaceutical tablets, guaranteeing the cocrystal content of the final pharmaceutical tablets in the solid state is critical. This study demonstrates the quantification of caffeine-glutaric acid cocrystals in model tablets using transmission low-frequency Raman spectroscopy. Although distinguishing between cocrystals and raw materials using conventional Raman spectroscopy is difficult, the use of low-frequency Raman spectroscopy enables the discrimination of cocrystals and raw materials. Low-frequency Raman spectra were analyzed by the partial least-squares method (PLS) to obtain the predicted contents in the model tablets. To evaluate the quantitative ability of this method, the root means square error of cross-validation (RMSECV) was determined by comparing the actual concentration and predicted content with a calibration curve. For cocrystal-containing tablets, the quantitative ability of the transmission mode (RMSECV = 2.06- 3.17) was 13.4-31.4% higher than that of the backscattering mode (RMSECV= 2.37- 3.91). The coexistence of raw crystalline materials did not affect the quantitative ability for cocrystals. |
| تدمد: | 1520-6882 0003-2700 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43dded1b5b7742a0b513cbba3d45e7 https://doi.org/10.1021/acs.analchem.9b01895 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7c43dded1b5b7742a0b513cbba3d45e7 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206882 00032700 |
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