Simultaneous Examination of Eosinophil Infiltration in Esophageal Mucosa and Muscle in Patients with Achalasia: Direct Biopsy of the Esophageal Muscle at Per-oral Endoscopic Myotomy
| العنوان: | Simultaneous Examination of Eosinophil Infiltration in Esophageal Mucosa and Muscle in Patients with Achalasia: Direct Biopsy of the Esophageal Muscle at Per-oral Endoscopic Myotomy |
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| المؤلفون: | Huimin Chen, Liang Xia, Qiang Cai, Lianyong Li, Steve Keilin, Lucie F. Calderon, Rushikesh Shah, Yue Xue, Wei Wang, Baiwen Li, Wei Zheng |
| المصدر: | Digestive Diseases and Sciences |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Natural Orifice Endoscopic Surgery, Myotomy, medicine.medical_specialty, Esophageal Mucosa, Physiology, Biopsy, medicine.medical_treatment, POEM, Achalasia, Pathophysiology, Gastroenterology, Muscular layer, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Eosinophilic esophagitis (EoE), Outcome Assessment, Health Care, otorhinolaryngologic diseases, medicine, Humans, Esophagus, Eosinophilic esophagitis, Muscle biopsy, medicine.diagnostic_test, business.industry, Muscles, Eosinophilic Esophagitis, Middle Aged, medicine.disease, Eosinophils, Esophageal Achalasia, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Original Article, Female, 030211 gastroenterology & hepatology, Esophagoscopy, Complication, business |
| الوصف: | Background The relationship between eosinophilic esophagitis (EoE) and achalasia is not completely understood. There have been reports of eosinophilic infiltration of all esophageal layers in patients with achalasia. However, a routine endoscopic biopsy of the muscular layer is usually not feasible. We evaluate the safety and efficacy of muscle layer biopsy during per-oral endoscopic myotomy (POEM) as well as the prevalence of eosinophilic infiltration of the esophageal mucosa and muscular layer in patients with achalasia. Patients and Methods All enrolled patients had diagnosed achalasia and had simultaneous biopsies of the muscular layer at the middle esophagus and distal esophageal sphincter as well as the mucosal layer of the proximal and distal esophagus during POEM. All POEM procedures took place from August 2018 to December 2018 or September 2019 to November 2019. Various demographic, disease-related, and procedure-related data were collected from chart review. Eosinophilic infiltration in the biopsy specimen was examined. Key Results Twenty consecutive patients (65% female, age range: 21–84) with a pre-procedure Eckardt score of >6 were enrolled during the study period, with the duration of their achalasia ranging from 1 to 32 years. Eighteen patients had clinical symptomatic improvement after POEM, as defined by an Eckardt score |
| تدمد: | 1573-2568 0163-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d683ed30d77bf86d67420286b3d3df5 https://doi.org/10.1007/s10620-021-06827-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d683ed30d77bf86d67420286b3d3df5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732568 01632116 |
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