Staphylococcus aureus bacteremia in immunosuppressed patients: a multicenter, retrospective cohort study
| العنوان: | Staphylococcus aureus bacteremia in immunosuppressed patients: a multicenter, retrospective cohort study |
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| المؤلفون: | Marilyn Steinberg, Anthony D. Bai, Adrienne Showler, Daniel R. Ricciuto, Sumit Raybardhan, G. Sasson, Andrew Morris, Eshan Fernando, Lisa Burry, Chaim M. Bell, Anna Chiu, Tania Fernandes |
| المصدر: | European Journal of Clinical Microbiology & Infectious Diseases. 36:1231-1241 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), Canada, Staphylococcus aureus, medicine.medical_specialty, Adolescent, medicine.medical_treatment, 030106 microbiology, Bacteremia, Immunocompromised Host, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Risk of mortality, Humans, 030212 general & internal medicine, Young adult, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Hazard ratio, Immunosuppression, Retrospective cohort study, General Medicine, Middle Aged, Staphylococcal Infections, Survival Analysis, Confidence interval, Surgery, Treatment Outcome, Infectious Diseases, Cohort, Female, business |
| الوصف: | Staphylococcus aureus bacteremia (SAB) causes significant morbidity and mortality. We assessed the disease severity and clinical outcomes of SAB in patients with pre-existing immunosuppression, compared with immunocompetent patients. A retrospective cohort investigation studied consecutive patients with SAB hospitalized across six hospitals in Toronto, Canada from 2007 to 2010. Patients were divided into immunosuppressed (IS) and immunocompetent (IC) cohorts; the IS cohort was subdivided into presence of one and two or more immunosuppressive conditions. Clinical parameters were compared between cohorts and between IS subgroups. A competing risk model compared in-hospital mortality and time to discharge. A total of 907 patients were included, 716 (79%) were IC and 191 (21%) were IS. Within the IS cohort, 111 (58%) had one immunosuppressive condition and 80 (42%) had two or more conditions. The overall in-hospital mortality was 29%, with no differences between groups (IS 32%, IC 28%, p = 0.4211). There were no differences in in-hospital mortality (sub-distribution hazard ratio [sHR] 1.17, 95% confidence interval [CI] 0.88–1.56, p = 0.2827) or time to discharge (sHR 0.94, 95% CI 0.78–1.15, p = 0.5570). Independent mortality predictors for both cohorts included hypotension at 72 h (IS: p |
| تدمد: | 1435-4373 0934-9723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9dce2faa7310ae2ac80945d823c05d https://doi.org/10.1007/s10096-017-2914-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7e9dce2faa7310ae2ac80945d823c05d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14354373 09349723 |
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