Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination
| العنوان: | Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination |
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| المؤلفون: | Zhuman Lv, Wenlin Li, Guanyu Zhang, Zhe-Peng Liu, Jing Wang, Haini Chen, Yijun Li, Shoujin Zhao |
| المصدر: | Polymers Volume 13 Issue 20 Polymers, Vol 13, Iss 3595, p 3595 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Materials science, Polymers and Plastics, extracellular matrix, Organic chemistry, coaxial electrospinning, Article, Contact angle, Chitosan, chemistry.chemical_compound, Differential scanning calorimetry, QD241-441, Hyaluronic acid, medicine, Fourier transform infrared spectroscopy, chemistry.chemical_classification, technology, industry, and agriculture, water-soluble materials, myelination, General Chemistry, Polymer, Oligodendrocyte, medicine.anatomical_structure, chemistry, Chemical engineering, Coaxial, oligodendrocyte |
| الوصف: | Myelin sheaths are essential in maintaining the integrity of axons. Development of the platform for in vitro myelination would be especially useful for demyelinating disease modeling and drug screening. In this study, a fiber scaffold with a core–shell structure was prepared in one step by the coaxial electrospinning method. A high-molecular-weight polymer poly-L-lactic acid (PLLA) was used as the core, while the shell was a natural polymer material such as hyaluronic acid (HA), sodium alginate (SA), or chitosan (CS). The morphology, differential scanning calorimetry (DSC), Fourier transform infrared spectra (FTIR), contact angle, viability assay, and in vitro myelination by oligodendrocytes were characterized. The results showed that such fibers are bead-free and continuous, with an average size from 294 ± 53 to 390 ± 54 nm. The DSC and FTIR curves indicated no changes in the phase state of coaxial brackets. Hyaluronic acid/PLLA coaxial fibers had the minimum contact angle (53.1° ± 0.24°). Myelin sheaths were wrapped around a coaxial electrospun scaffold modified with water-soluble materials after a 14-day incubation. All results suggest that such a scaffold prepared by coaxial electrospinning potentially provides a novel platform for oligodendrocyte myelination. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4360 |
| DOI: | 10.3390/polym13203595 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4c025edbbc8c5e12b6671927d85bf7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7f4c025edbbc8c5e12b6671927d85bf7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734360 |
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| DOI: | 10.3390/polym13203595 |