Cardiorespiratory Fitness, BMI, Mortality, and Cardiovascular Disease in Adults with Overweight/Obesity and Type 2 Diabetes
| العنوان: | Cardiorespiratory Fitness, BMI, Mortality, and Cardiovascular Disease in Adults with Overweight/Obesity and Type 2 Diabetes |
|---|---|
| المؤلفون: | Andrew C, Wills, Elsa, Vazquez Arreola, Muideen T, Olaiya, Jeffrey M, Curtis, Margareta I, Hellgren, Robert L, Hanson, William C, Knowler |
| المصدر: | Med Sci Sports Exerc |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Physical Therapy, Sports Therapy and Rehabilitation, Middle Aged, Overweight, Article, Body Mass Index, Cardiorespiratory Fitness, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Physical Fitness, Risk Factors, Exercise Test, Humans, Orthopedics and Sports Medicine, Obesity, Aged |
| الوصف: | INTRODUCTION: We estimated the effects of cardiorespiratory fitness (CRF) and body mass index (BMI) at baseline on mortality and cardiovascular disease events in people with type 2 diabetes that participated in the Look AHEAD randomized clinical trial. METHODS: Look AHEAD compared effects of an intensive lifestyle intervention with diabetes support and education on cardiovascular disease events in 5,145 adults aged 45–76 years with overweight/obesity and type 2 diabetes. In 4,773 participants, we performed a secondary analysis of the association of baseline CRF during maximal treadmill test (expressed as metabolic equivalents, METs) on mortality and cardiovascular disease events during mean follow-up of 9.2 years. RESULTS: The mean (SD) CRF was 7.2 (2.0) METs. Adjusted for age, sex, race/ethnicity, body mass index, intervention group, and β-blocker use, all-cause mortality rate was 30% lower per SD greater METs (hazard ratio, HR=0.70, 95% CI 0.60–0.81; rate difference, RD=−2.71 deaths/1000 person-years, 95% CI −3.79 to −1.63). Similarly, a SD greater METs predicted lower cardiovascular disease mortality (HR=0.45, RD =−1.65 cases/1000 person-years) and a composite cardiovascular outcome (HR= 0.72; RD=−6.38). Effects of METs were homogeneous on the HR scale for most baseline variables and outcomes but heterogeneous for many on the RD scale, with greater RDs in subgroups at greater risk of the outcomes. For example, all-cause mortality was lower by 7.6 deaths/1000 person-years per SD greater METs in those with a history of cardiovascular disease at baseline but lower by only 1.6 in those without such history. BMI adjusted for CRF had little or no effect on these outcomes. CONCLUSIONS: Greater CRF is associated with reduced risks of mortality and cardiovascular disease events. |
| تدمد: | 1530-0315 0195-9131 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8124c9c4878872085e44c4b1e7e502d5 https://doi.org/10.1249/mss.0000000000002873 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8124c9c4878872085e44c4b1e7e502d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300315 01959131 |
|---|