Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis
| العنوان: | Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated Analysis |
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| المؤلفون: | Xiao-Ping Shen, Yu-Feng Mao, Yamei Hai, Xiao-Na Zhang, Yu Zhao, Yi-Yang Hu, Lin Xu, Yi-Shuang Tang, Jian-Chun Guo |
| المصدر: | Chinese Journal of Integrative Medicine. 28:28-35 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hepatitis B virus, medicine.medical_specialty, Necrosis, T-Lymphocytes, 0211 other engineering and technologies, 02 engineering and technology, Traditional Chinese medicine, 030226 pharmacology & pharmacy, Gastroenterology, Transcriptome, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Tongue, Internal medicine, 021105 building & construction, Humans, Metabolomics, Medicine, Pharmacology (medical), Gene, Pathological, business.industry, Fatty Acids, General Medicine, Metabolism, medicine.anatomical_structure, Complementary and alternative medicine, Apoptosis, medicine.symptom, business |
| الوصف: | To compare the circular pathological changes of chronic hepatitis B (CHB) patients according to the tongue diagnosis. Totally 41 CHB patients with typical white tongue coating (WTC) or yellow tongue coating (YTC) were enrolled and 14 healthy volunteers with normal tongue manifestation served as controls. The mRNA expression of peripheral leukocytes was detected by GeneChips, and 9 genes were randomly selected for expression validation. Circular metabolites were detected by gas chromatographymass spectrometry. Biological information was analyzed based on ingenuity pathways analysis or metabolomics database and the integrated networks were constructed by ClueGO. A total of 945 and 716 differentially expressed genes were found in patients with WTC and YTC relative to healthy volunteers respectively. The biological information analysis indicated that CHB patients had obviously increased functions in cell death, apoptosis and necrosis (Z-score ⩾2, P |
| تدمد: | 1993-0402 1672-0415 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8199dd7f298b60f2b404ef177f8837be https://doi.org/10.1007/s11655-020-3275-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8199dd7f298b60f2b404ef177f8837be |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 19930402 16720415 |
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