Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study
| العنوان: | Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study |
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| المؤلفون: | Kalpana Luthra, Manju Bala, Rajesh Kalra, Raiees Andrabi, Alok K. Chaudhury, Ashutosh Biswas, Shubhasree Dutta Choudhury, Naveet Wig |
| المصدر: | Archives of Virology. 155:563-569 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Molecular Sequence Data, Mutation, Missense, India, Sequence Homology, HIV Infections, Drug resistance, medicine.disease_cause, Virus, Young Adult, Medical microbiology, Virology, Drug Resistance, Viral, medicine, Cluster Analysis, Humans, Gene, Phylogeny, Mutation, biology, Reverse-transcriptase inhibitor, Sequence Analysis, DNA, General Medicine, Middle Aged, biology.organism_classification, HIV Reverse Transcriptase, Multiple drug resistance, Amino Acid Substitution, Anti-Retroviral Agents, Lentivirus, HIV-1, Female, Follow-Up Studies, medicine.drug |
| الوصف: | The viral reverse transcriptase gene was amplified from the plasma of 27 drug-naïve and five drug-experienced HIV patients in Northern India. Follow-up samples of naïve patients after antiretroviral therapy initiation were collected in six patients at 3 months and three patients at 6 months. Phylogenetic analysis revealed two new recombinant forms, CRF_CH and CRF_CK, and an accessory non-nucleoside reverse transcriptase inhibitor mutation E138A, not previously reported from India. The major DRMs found in two 6-month follow-up samples were absent in their baseline blood samples. This is the first follow-up study to determine anti-retroviral drug resistance mutations in Indian HIV patients. |
| تدمد: | 1432-8798 0304-8608 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838496dcae75aa89a14cb458f5f0503a https://doi.org/10.1007/s00705-010-0605-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....838496dcae75aa89a14cb458f5f0503a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14328798 03048608 |
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