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Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

التفاصيل البيبلوغرافية
العنوان: Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease
المؤلفون: Sophia G. Antimisiaris, Ihsen Youssef, Adina N. Lazar, Charles Duyckaerts, Christophe Parizot, Aurélien Dauphin, Spyridon Mourtas, Benoît Delatour
المساهمون: FRAMATOME, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neurologie et thérapeutique expérimentale, IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
المصدر: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine
Nanomedicine, 2013, 9 (5), pp.712-21. ⟨10.1016/j.nano.2012.11.004⟩
سنة النشر: 2013
مصطلحات موضوعية: Curcumin, Materials science, Amyloid, [SDV]Life Sciences [q-bio], Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Neocortex, Bioengineering, Pharmacology, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Alzheimer Disease, In vivo, medicine, Animals, Humans, General Materials Science, Senile plaques, Coloring Agents, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, P3 peptide, Peptide secretion, medicine.disease, Peptide Fragments, 3. Good health, Targeted drug delivery, chemistry, Biochemistry, Liposomes, Nanoparticles, Molecular Medicine, Autopsy, Alzheimer's disease, 030217 neurology & neurosurgery
الوصف: Accumulation of amyloid peptide (Aβ) in senile plaques is a hallmark lesion of Alzheimer disease (AD). The design of molecules able to target the amyloid pathology in tissue is receiving increasing attention, both for diagnostic and for therapeutic purposes. Curcumin is a fluorescent molecule with high affinity for the Aβ peptide but its low solubility limits its clinical use. Curcumin-conjugated nanoliposomes, with curcumin exposed at the surface, were designed. They appeared to be monodisperse and stable. They were non-toxic in vitro, down-regulated the secretion of amyloid peptide and partially prevented Aβ-induced toxicity. They strongly labeled Aβ deposits in post-mortem brain tissue of AD patients and APPxPS1 mice. Injection in the hippocampus and in the neocortex of these mice showed that curcumin-conjugated nanoliposomes were able to specifically stain the Aβ deposits in vivo. Curcumin-conjugated nanoliposomes could find application in the diagnosis and targeted drug delivery in AD. From the Clinical Editor In this preclinical study, curcumin-conjugated nanoliposomes were investigated as possible diagnostics and targeted drug delivery system in Alzheimer’s disease, demonstrating strong labeling of Aβ deposits both in human tissue and in mice, and in vitro downregulation of amyloid peptide secretion and prevention of Aβ-induced toxicity.
اللغة: English
تدمد: 1549-9634
DOI: 10.1016/j.nano.2012.11.004
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849436a90389de7ddc3c5b4ca9a72f39
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....849436a90389de7ddc3c5b4ca9a72f39
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15499634
DOI:10.1016/j.nano.2012.11.004