Diversity of Toxoplasma gondii strains shaped by commensal communities of small mammals
| العنوان: | Diversity of Toxoplasma gondii strains shaped by commensal communities of small mammals |
|---|---|
| المؤلفون: | Carine Brouat, Dominique Aubert, Camille Dubois, Marie-Laure Dardé, Mamadou Kane, Gereon Schares, Aurélien Mercier, Lokman Galal, Daniel Ajzenberg, Youssoupha Niang, Aliou Sow, Thomas Cuny, Claire Stragier, Azra Hamidović, Clément Glodas, Mamoudou Diallo, Philippe Vignoles, Thao Rohart |
| المساهمون: | Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre Hospitalier Universitaire de Reims (CHU Reims), Université de Limoges (UNILIM), Institute of Epidemiology (IfE), Friedrich-Loeffler-Institut (FLI), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), CHU Limoges, Institut de recherche pour le développement (IRD [Sénégal]), Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), French Agence Nationale de la Recherche (ANR project IntroTox) : 17-CE35-0004, University of Limoges, France, Nouvelle-Aquitaine region (Directorate of Research, Higher Education and Technology Transfer), ANR-17-CE35-0004,IntroTox,PHENOMÈNES D'INTROGRESSIONS DANS L'ÉTUDE DE LA DIVERSITÉ GÉNÉTIQUE DU TOXOPLASME ENTRE LA FRANCE ET L'AFRIQUE DE L'OUEST ET CENTRALE : DES INFLUENCES HUMAINES ET ENVIRONEMENTALES(2017) |
| المصدر: | International Journal for Parasitology International Journal for Parasitology, Elsevier, 2018 International Journal for Parasitology, Elsevier, 2019, 49 (3-4), pp.267-275. ⟨10.1016/j.ijpara.2018.11.004⟩ International Journal for Parasitology, 2019, 49 (3-4), pp.267-275. ⟨10.1016/j.ijpara.2018.11.004⟩ |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Genotype, Genotyping Techniques, Rodent, 030231 tropical medicine, Toxoplasma gondii, Neospora caninum, Zoology, Rodentia, Introduced species, Biology, Rodents, Genetic diversity, House mouse, Serology, Rodent Diseases, 03 medical and health sciences, 0302 clinical medicine, biology.animal, West Africa, parasitic diseases, Prevalence, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, ComputingMilieux_MISCELLANEOUS, Hammondia, [SDV.BA]Life Sciences [q-bio]/Animal biology, Genetic Variation, biology.organism_classification, Biota, Senegal, Toxoplasmosis, Animal, 030104 developmental biology, Infectious Diseases, Parasitology, House mice, Toxoplasma, Microsatellite Repeats |
| الوصف: | International audience; Commensal rodent species are key reservoirs for Toxoplasma gondii in the domestic environment. In rodents, different T. gondii strains show variable patterns of virulence according to host species. Toxoplasma gondii strains causing non-lethal chronic infections in local hosts will be more likely to persist in a given environment, but few studies have addressed the possible role of these interactions in shaping the T. gondii population structure. In addition, the absence of validated techniques for upstream detection of T. gondii chronic infection in wild rodents hinders exploration of this issue under natural conditions. In this study, we took advantage of an extensive survey of commensal small mammals in three coastal localities of Senegal, with a species assemblage constituted of both native African species and invasive species. We tested 828 individuals for T. gondii chronic infection using the modified agglutination test for antibody detection in serum samples and a quantitative PCR assay for detection of 7'. gondii DNA in brain samples. The infecting 7'. gondii strains were genotyped whenever possible by the analysis of 15 microsatellite markers. We found (i) a very poor concordance between molecular detection and serology in the invasive house mouse, (ii) significantly different levels of prevalence by species and (iii) the autochthonous T. gondii Africa 1 lineage strains, which are lethal for laboratory mice, only in the native African species of commensal small mammals. Overall, this study highlights the need to reconsider the use of MAT serology in natural populations of house mice and provides the first known data about T. gondii genetic diversity in invasive and native species of small mammals from Africa. In light of these results, we discuss the role of invasive and native species, with their variable adaptations to different T. gondii strains, in shaping the spatial structure of 7'. gondii genetic diversity in Africa. |
| تدمد: | 0020-7519 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec93e4fb7e564cb71fa82d4b544837 https://doi.org/10.1016/j.ijpara.2018.11.004 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....87ec93e4fb7e564cb71fa82d4b544837 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00207519 |
|---|