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Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells

التفاصيل البيبلوغرافية
العنوان: Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells
المؤلفون: Feng Yin, Liangyu Lu, Aoyuan Fan, Guojian Fu, Zhangyi Pan
المصدر: Regenerative Medicine. 16:359-372
بيانات النشر: Future Medicine Ltd, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Embryology, Cell, Biomedical Engineering, Adipose tissue, macromolecular substances, Exosomes, Tendons, Rotator Cuff, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Rotator cuff, 030304 developmental biology, 030222 orthopedics, 0303 health sciences, business.industry, Stem Cells, Rotator cuff injury, fungi, musculoskeletal system, medicine.disease, Microvesicles, Rats, Cell biology, carbohydrates (lipids), RUNX2, medicine.anatomical_structure, Adipose Tissue, Adipogenesis, Stem cell, business
الوصف: Aim: To evaluate the potential capability of adipose-derived stem cell exosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. Methods: First, we investigated the growth, survival and migration of TDSCs in the presence of ADSC-exos in vitro. Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing in vivo. Results: The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of RUNX2, Sox-9, TNMD, TNC and Scx and the mechanical properties of the articular portion. Conclusion: The ADSC-exos have the potential to promote the rotator cuff repair by mediating the TDSCs.
تدمد: 1746-076X
1746-0751
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e183abf504c4b314f019e3848bce40
https://doi.org/10.2217/rme-2021-0004
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....88e183abf504c4b314f019e3848bce40
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1746076X
17460751