Determination of warfarin in animal relicta and feedingstuffs by high-pressure liquid chromatography with confirmation of identity by mass spectrometry
التفاصيل البيبلوغرافية
العنوان:
Determination of warfarin in animal relicta and feedingstuffs by high-pressure liquid chromatography with confirmation of identity by mass spectrometry
The determination of warfarin in liver, blood, urine and feedingstuffs by high-pressure liquid chromatography (HPLC) is described. Clean-up is simple and the lower limit of determination is about 0.025 ppm. Recoveries from liver are about 85% over the range 0.025–1.0 ppm; recoveries from blood range from about 67 to 90%. Chemical ionisation mass spectrometry can be used to confirm identity and, by specific ion monitoring, to detect warfarin in HPLC eluates at levels below the sensitivity of the HPLC detector.
