Antiviral (Hepatitis C Virus) Drug-Drug Interaction Leading to Dramatic Underestimation of Liver Function With 99mTc-Mebrofenin Hepatobiliary Scintigraphy
| العنوان: | Antiviral (Hepatitis C Virus) Drug-Drug Interaction Leading to Dramatic Underestimation of Liver Function With 99mTc-Mebrofenin Hepatobiliary Scintigraphy |
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| المؤلفون: | Boris Guiu, Lucy Meunier, Cyril Fersing, François Quenet, Emmanuel Deshayes |
| المساهمون: | Institut du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département radiologie diagnostique et interventionnelle Saint Eloi [CHRU Montpellier], Pôle Digestif [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| المصدر: | Clinical Nuclear Medicine Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2020, 45 (2), pp.133-135. ⟨10.1097/RLU.0000000000002861⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cyclopropanes, Colorectal cancer, MESH: Drug Interactions, MESH: Sulfonamides, Hepacivirus, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Scintigraphy, medicine.disease_cause, Gastroenterology, 030218 nuclear medicine & medical imaging, Metastasis, 0302 clinical medicine, MESH: Cyclopropanes, MESH: Radionuclide Imaging, Medicine, Drug Interactions, MESH: Hepacivirus, Hypoalbuminemia, MESH: Imino Acids, Sulfonamides, Aniline Compounds, medicine.diagnostic_test, Imidazoles, General Medicine, Organotechnetium Compounds, MESH: Amides, 3. Good health, Grazoprevir, 030220 oncology & carcinogenesis, Female, MESH: Imidazoles, MESH: Radiopharmaceuticals, Adult, MESH: Antiviral Agents, medicine.medical_specialty, Elbasvir, Hepatitis C virus, Glycine, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Antiviral Agents, 03 medical and health sciences, MESH: Organotechnetium Compounds, MESH: Quinoxalines, Internal medicine, Quinoxalines, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Benzofurans, MESH: Liver Failure, MESH: Humans, MESH: Carbamates, business.industry, Imino Acids, MESH: Benzofurans, MESH: Adult, medicine.disease, Amides, Liver function, Carbamates, Radiopharmaceuticals, business, MESH: Female, Liver Failure |
| الوصف: | International audience; There is a growing interest in assessment of future remnant liver function with Tc-mebrofenin hepatobiliary scintigraphy before major hepatectomy to estimate the risk of posthepatectomy liver failure. We illustrate the case of a 42-year-old woman with liver metastasis from colorectal cancer who performed hepatobiliary scintigraphy. Tc-mebrofenin clearance rate of the total liver was considerably low. The patient recently started a treatment for active hepatitis C with a combination of 2 new direct-acting antiviral agents (grazoprevir, elbasvir). Apart from hypoalbuminemia or hyperbilirubinemia, physicians must be aware that drug interactions can interfere with Tc-mebrofenin liver uptake, thereby resulting in a dramatic underestimation of liver function. |
| اللغة: | English |
| تدمد: | 0363-9762 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bebe2ff94a4c28fbeced4709ba214ff https://hal.umontpellier.fr/hal-03384686 |
| رقم الأكسشن: | edsair.doi.dedup.....8bebe2ff94a4c28fbeced4709ba214ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03639762 |
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