Comparison of lifibrol to other lipid-regulating agents in experimental animals
العنوان: | Comparison of lifibrol to other lipid-regulating agents in experimental animals |
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المؤلفون: | Brian R. Krause, R. F. Bousley, R. L. Stanfield, Donald G. Robertson, K.A. Kieft, Roger S. Newton, Ellen Urda |
المصدر: | Pharmacological research. 29(4) |
سنة النشر: | 1994 |
مصطلحات موضوعية: | Male, medicine.medical_specialty, Butanols, Lipoproteins, Guinea Pigs, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Internal medicine, polycyclic compounds, medicine, Hydroxybenzoates, Gemfibrozil, Animals, Lovastatin, Hypolipidemic Agents, Pharmacology, biology, Cholesterol, nutritional and metabolic diseases, Biological activity, Hydroxymethylglutaryl-CoA reductase, Lipids, Rats, Sterols, Endocrinology, chemistry, Enzyme inhibitor, HMG-CoA reductase, biology.protein, lipids (amino acids, peptides, and proteins), medicine.drug |
الوصف: | In vitro data suggests that lifibrol lowers plasma cholesterol by inhibiting cholesterol synthesis. We report that lifibrol is far less potent in vitro and in vivo than lovastatin for inhibiting 14 C-acetate incorporation into sterols. Moreover, several major differences between lifobrol and lovastatin were noted in various animal models. In contrast, lifibrol exhibited several activities in common with gemfibrozil, another phenoxy-acid-type drug. Specifically, in normal rats lifibrol, like gemfibrozil, lowered plasma non- HDL-cholesterol and triglycerides, and increased liver weight and hepatic peroxisomal marker enzyme activities. Lovastatin only lowered plasma triglycerides. In cholesterol-fed rats lifibrol and gemfibrozil lowered non-HDL-cholesterol and elevated HDL-cholesterol while lovastatin was inactive. Finally, lovastatin but not lifibrol exhibited hypocholesterolemic activity in normal guinea pigs and resin-primed dogs. Our interpretation is that these data do not support the notion that lifibrol lowers plasma cholesterol in vivo by inhibiting cholesterol synthesis. |
تدمد: | 1043-6618 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce199aa35582b19ef409a0e56e2209c https://pubmed.ncbi.nlm.nih.gov/7971686 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....8ce199aa35582b19ef409a0e56e2209c |
قاعدة البيانات: | OpenAIRE |
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