Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats
| العنوان: | Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats |
|---|---|
| المؤلفون: | Chao Liu, Jie Hu, Zhi Mao, Wan-Lei Fu, Yang-Fan Lv, Hongjun Kang, Hui Liu, Feihu Zhou |
| المصدر: | Clinical Interventions in Aging |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cochlear Nucleus, Male, 0301 basic medicine, Premature aging, Aging, aging rat, medicine.medical_specialty, Gastroenterology, d-galactose, Rats, Sprague-Dawley, Sepsis, 03 medical and health sciences, Subcutaneous injection, chemistry.chemical_compound, Internal medicine, medicine, Animals, Cecum, Ligation, Blood urea nitrogen, Original Research, Creatinine, business.industry, cecal ligation and puncture, Acute kidney injury, Brain, Galactose, NADPH Oxidases, inflammatory response, General Medicine, Acute Kidney Injury, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, Clinical Interventions in Aging, Increased inflammatory response, Tumor necrosis factor alpha, Geriatrics and Gerontology, business |
| الوصف: | Chao Liu,1,* Jie Hu,1,* Zhi Mao,1,* Hongjun Kang,1 Hui Liu,1 Wanlei Fu,2 Yangfan Lv,2 Feihu Zhou1 1Department of Critical Care Medicine, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Recently, the D-galactose (D-gal)-induced mimetic aging rat model has been widely used in studies of age-associated diseases, which have shown that chronic D-gal exposure induces premature aging similar to natural aging in rats. With the increasing rate of sepsis in the geriatric population, an easy-access animal model for preclinical studies of elderly sepsis is urgently needed. This study investigates whether a sepsis model that is established in D-gal-induced aging rats can serve as a suitable model for preclinical studies of elderly patients with sepsis.Objective: To investigate the acute kidney injury (AKI) and inflammatory response of sepsis following cecal ligation and puncture (CLP) in D-gal-induced aging rats.Methods: Twelve-week-old male Sprague Dawley rats were divided into low-dose D-gal (L D-gal, 125 mg/kg/d), high-dose D-gal (H D-gal, 500 mg/kg/d), and control groups. After daily subcutaneous injection of D-gal for 6 weeks, the CLP method was used to establish a sepsis model.Results: The mortality was 73.3%, 40%, and 33.3% in the H D-gal, L D-gal, and control groups, respectively. Blood urea nitrogen, creatinine, plasma neutrophil gelatinase-associated lipocalin, interleukin-6, interleukin-10, and tumor necrosis factor-α were markedly increased in the H D-gal group after establishment of the sepsis model (H D-gal vs control, P |
| وصف الملف: | text/html |
| تدمد: | 1178-1998 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e677bdc17bfb876a79698bef2a5c7ac https://doi.org/10.2147/cia.s132277 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8e677bdc17bfb876a79698bef2a5c7ac |
| قاعدة البيانات: | OpenAIRE |
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