Comorbidity of chronic disease and potential treatment conflicts in older people dispensed antidepressants
| العنوان: | Comorbidity of chronic disease and potential treatment conflicts in older people dispensed antidepressants |
|---|---|
| المؤلفون: | Agnes Vitry, Andrew L. Gilbert, Sepehr Shakib, Gillian E. Caughey, Elizabeth E. Roughead, Robyn McDermott |
| المساهمون: | Caughey, Gillian Elizabeth, Roughead, Elizabeth Ellen, Shakib, Sephr, McDermott, Robyn A, Vitry, Agnes I, Gilbert, Andrew Leigh |
| المصدر: | Age and Ageing. 39:488-494 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Cross-sectional study, Osteoporosis, Pain, Comorbidity, Anxiety, elderly, Drug Incompatibility, Pharmacotherapy, medicine, Humans, Medication Errors, Psychiatry, Adverse effect, Depression (differential diagnoses), Aged, Aged, 80 and over, antidepressant, Depression, business.industry, Arthritis, Australia, General Medicine, medicine.disease, Antidepressive Agents, comorbidity, Cross-Sectional Studies, Cardiovascular Diseases, Chronic Disease, Practice Guidelines as Topic, depression, Cohort, Female, Geriatrics and Gerontology, medicine.symptom, business, chronic disease |
| الوصف: | Objectives: the study aimed to examine the prevalence of comorbidity, the prescribing of potentially inappropriate medications and treatment conflicts in a large sample of older people who have been dispensed an antidepressant medicine. Conclusion: we observed a high level of potentially inappropriate prescribing and treatment conflicts that may arise when caring for older patients dispensed an antidepressant with comorbidity. These have the potential to place a large number of older people with depression at increased risk for adverse events. Methods: a cross-sectional study of administrative claims data from the Department of Veterans' Affairs, Australia, 1 April-31 July 2007, of veterans aged =65 years was conducted. Comorbidities determined using the pharmaceutical-based comorbidity index, Rx-Risk-V. Concomitant medicines that may be potentially inappropriate for patients with depression and areas of treatment conflicts were determined from Australian clinical guidelines or reference compendia. Results: a total of 39,695 subjects were included, with a median of 5 comorbid conditions (inter-quartile range 3-6). Ninety percent of medicine use was attributed to the treatment of comorbid conditions. Eighty-seven percent of the study cohort was identified as having at least one comorbid condition that may cause a potential treatment conflict when an antidepressant is used. Those conditions of most concern included cardiovascular diseases, anxiety disorders, arthritis or pain management and osteoporosis. Refereed/Peer-reviewed |
| تدمد: | 1468-2834 0002-0729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb6af5696bbaefd80b68c2795eebd5a https://doi.org/10.1093/ageing/afq055 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8eb6af5696bbaefd80b68c2795eebd5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682834 00020729 |
|---|