Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies
| العنوان: | Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies |
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| المؤلفون: | Ronald E. LaPorte, Allan L. Drash, Massimo Trucco, Massimo Pietropaolo, Susan L. Pietropaolo, Dorothy J. Becker, Karen Riley, Ingrid Libman, Shui Yu, Sati Mazumdar |
| المصدر: | Pediatric Diabetes. 6:184-192 |
| بيانات النشر: | Hindawi Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Diabetes risk, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Risk Assessment, Islets of Langerhans, Diabetes mellitus, Internal medicine, Prevalence, Internal Medicine, medicine, Animals, Humans, Family, Longitudinal Studies, Child, Autoantibodies, Type 1 diabetes, geography, Predictive marker, geography.geographical_feature_category, Glutamate Decarboxylase, business.industry, Insulin, Autoantibody, Infant, nutritional and metabolic diseases, medicine.disease, Islet, Rats, Isoenzymes, Diabetes Mellitus, Type 1, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, Immunology, Disease Progression, Female, business, Biomarkers |
| الوصف: | The discovery of islet cell antibodies (ICAs) was the prelude to the understanding that type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease. The issue regarding whether or not the measurement of ICAs should be completely replaced by biochemical markers detecting islet autoantibodies (AAs) for the prediction of T1DM has been the subject of endless international debates. In light of this controversy, we assessed the current role of ICAs as a predictive marker for T1DM progression. We examined a cohort of 1484 first-degree relatives (FDRs) of T1DM probands from the Children's Hospital of Pittsburgh Registry. These relatives were consecutively enrolled between 1979 through 1984 and followed up to 22 yr. Serum obtained at the time of enrollment was assayed for ICAs, glutamic acid decarboxylase (GAD)65, insulin A (IA)-2 AA, and insulin AAs (IAAs). In FDRs who had ICAs in addition to GAD65 and IA-2 AAs, the cumulative risk of developing insulin-requiring diabetes was 80% at 6.7 yr of follow-up, whereas this risk in those with GAD65 and IA-2 AAs without ICAs was only 14% at 10 yr of follow-up (log rank: P |
| تدمد: | 1399-5448 1399-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eda34801a588c55739b8f502561c75f https://doi.org/10.1111/j.1399-543x.2005.00127.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8eda34801a588c55739b8f502561c75f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13995448 1399543X |
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