Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
| العنوان: | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
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| المؤلفون: | Juan Francisco Merino-Torres, Alexia Andres, Stefan Prado-Wohlwend, Pilar Bello, María Isabel Del Olmo-García, José Miguel Soriano |
| المصدر: | del Olmo García, María Isabel Prado-Wohlwend, Stefan Andres, Alexia Soriano del Castillo, José Miguel Bello, Pilar Merino Torres, Juan Francisco 2021 Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms Biomedicines 9 12 1810 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Biomedicines Biomedicines, Vol 9, Iss 1810, p 1810 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system, QH301-705.5, Cell, Medicine (miscellaneous), Review, General Biochemistry, Genetics and Molecular Biology, medicine, Biology (General), Tumors, peptide receptor radionuclide therapy, Receptors d'hormones, neuroendocrine neoplasms, somatostatin analogues, Somatostatin receptor, business.industry, Treatment options, LU-DOTA-TATE, medicine.anatomical_structure, Somatostatin, Potential biomarkers, somatostatin receptors, somatostatin antagonists, Cancer research, 68Ga PET, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists. |
| تدمد: | 2227-9059 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900f32a78ad4d7cbdb854058ec66e26a https://doi.org/10.3390/biomedicines9121810 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....900f32a78ad4d7cbdb854058ec66e26a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22279059 |
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