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Non-invasive assessment of failure torque in rat bones with simulated lytic lesions using computed tomography based structural rigidity analysis

التفاصيل البيبلوغرافية
العنوان: Non-invasive assessment of failure torque in rat bones with simulated lytic lesions using computed tomography based structural rigidity analysis
المؤلفون: Vartan Vartanians, Ara Nazarian, David Zurakowski, Vahid Entezari, Pamela Basto, Brian D. Snyder
المصدر: Journal of Biomechanics. 44:552-556
بيانات النشر: Elsevier BV, 2011.
سنة النشر: 2011
مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Materials science, Bone density, Biomedical Engineering, Biophysics, Article, Rats, Sprague-Dawley, Bone Density, medicine, Animals, Torque, Orthopedics and Sports Medicine, Femur, Structural rigidity, Dual-energy X-ray absorptiometry, Bone mineral, medicine.diagnostic_test, Rehabilitation, Torsion (mechanics), Biomechanical Phenomena, Rats, Surgery, Female, Tomography, Tomography, X-Ray Computed, Biomedical engineering
الوصف: This study applies CT-based structural rigidity analysis (CTRA) to assess failure torque of rat femurs with simulated lytic defects at different locations (proximal and distal femur) and diameters (25% and 50% of the cross-section at the site), and compared the results to those obtained from mechanical testing. Moreover, it aims to compare the correlation coefficients between CTRA-based failure torque and DXA-based aBMD versus actual failure torque. Twenty rats were randomly assigned to four equal groups of different simulated lesions based on size and location. Femurs from each animal underwent micro-computed tomography to assess three-dimensional micro-structural data, torsional rigidity using structural rigidity analysis and dual energy X-ray absorptiometry to assess bone mineral density. Following imaging, all specimens were subjected to torsion. Failure torque predicted from CT-derived structural rigidity measurements was better correlated with mechanically derived failure torque [R2=0.85] than was aBMD from DXA [R2=0.32]. In summary, the results of this study suggest that computed tomography based structural rigidity analysis can be used to accurately and quantitatively measure the mechanical failure torque of bones with osteolytic lesions in an experimental rat model. Structural rigidity analysis can provide more accurate predictions on maximal torque to mechanical failure than dual energy X-ray absorptiometry based on bone mineral density.
تدمد: 0021-9290
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9174bcb5c7b645874fa7407c59bf731d
https://doi.org/10.1016/j.jbiomech.2010.09.022
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9174bcb5c7b645874fa7407c59bf731d
قاعدة البيانات: OpenAIRE
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