Delivery of neurotrophic factors and therapeutic proteins for retinal diseases
| العنوان: | Delivery of neurotrophic factors and therapeutic proteins for retinal diseases |
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| المؤلفون: | Dwaine F. Emerich, Chris Thanos |
| المصدر: | Expert Opinion on Biological Therapy. 5:1443-1452 |
| بيانات النشر: | Informa Healthcare, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Retinal degeneration, Clinical Biochemistry, Ciliary neurotrophic factor, Protein Engineering, Bioinformatics, Neuroprotection, Drug Delivery Systems, PEDF, Retinal Diseases, Neurotrophic factors, Drug Discovery, Retinitis pigmentosa, medicine, Glial cell line-derived neurotrophic factor, Animals, Humans, Nerve Growth Factors, Pharmacology, biology, business.industry, Genetic Therapy, Anatomy, Macular degeneration, medicine.disease, biology.protein, business |
| الوصف: | Neurotrophic factors have the ability to protect and initiate growth of neurons. In the central nervous system, neurotrophic factors are neuroprotective in a wide range of disease states. Similarly, disease pathologies of the neurosensory retina respond favourably in animal models of retinitis pigmentosa, macular degeneration, glaucoma and others. With advances in drug delivery and cell therapy, an almost universal increase in efficacy is being realised. Now, repeated injections of neurotrophic factors are being replaced by controlled delivery of cell-mediated factor secretion, reducing the number of potential acute side effects. Tissue engineering strategies in conjunction with gene-modulated protein therapy or gene transfer are creating a unique treatment niche and are quickly gaining acclaim in the clinic. This review surveys the founding and current work on neurotrophic factors such as CNTF, BDNF, GDNF, LEDGF, PEDF and others. Ongoing clinical trials and successful preclinical studies are summarised as well. |
| تدمد: | 1744-7682 1471-2598 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9248b1ce7759bfa28e042bf876750331 https://doi.org/10.1517/14712598.5.11.1443 |
| رقم الأكسشن: | edsair.doi.dedup.....9248b1ce7759bfa28e042bf876750331 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17447682 14712598 |
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