Successful treatment of anti-factor H antibody-associated atypical hemolytic uremic syndrome
| العنوان: | Successful treatment of anti-factor H antibody-associated atypical hemolytic uremic syndrome |
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| المؤلفون: | Masatsugu Uehara, Tomoo Kise, Shigeru Fukuyama |
| المصدر: | Indian Journal of Nephrology, Vol 30, Iss 1, Pp 35-38 (2020) Indian Journal of Nephrology |
| بيانات النشر: | Medknow, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, anti-cfh antibody, 030232 urology & nephrology, Case Report, 030230 surgery, lcsh:RC870-923, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Maintenance therapy, Internal medicine, Atypical hemolytic uremic syndrome, medicine, child, biology, business.industry, Autoantibody, Eculizumab, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, eye diseases, Discontinuation, ahus, Nephrology, Bacteremia, biology.protein, Prednisolone, eculizumab, Antibody, business, medicine.drug |
| الوصف: | Anti-complement factor H (CFH) autoantibody (Ab)-associated atypical hemolytic uremic syndrome (aHUS) has a poor prognosis in terms of frequent relapses. Although eculizumab is an effective treatment for this type of aHUS, the method of eculizumab discontinuation is not yet established. Herein, we report a case of anti-CFH Ab-associated aHUS in a 6-year-old boy. Eculizumab induction therapy following plasma exchange improved his condition. After 14 months, eculizumab was discontinued because of meningococcal bacteremia. After 6 months of eculizumab cessation, prednisolone (20 mg/alternate days) and mycophenolate mofetil (500 mg/day) were initiated. There were no relapses or increases in anti-CFH Ab titers for 26 months after treatment initiation. We believe that eculizumab induction therapy, following plasma exchange and maintenance therapy with immunosuppressants after eculizumab discontinuation are effective treatments for anti-CFH Ab-related aHUS. |
| تدمد: | 0971-4065 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a6b43102151f59cb07bd0f332ffb19 https://doi.org/10.4103/ijn.ijn_336_18 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....92a6b43102151f59cb07bd0f332ffb19 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09714065 |
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