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Lipiodol as an Imaging Biomarker of Tumor Response After Conventional Transarterial Chemoembolization: Prospective Clinical Validation in Patients with Primary and Secondary Liver Cancer

التفاصيل البيبلوغرافية
العنوان: Lipiodol as an Imaging Biomarker of Tumor Response After Conventional Transarterial Chemoembolization: Prospective Clinical Validation in Patients with Primary and Secondary Liver Cancer
المؤلفون: Arash Fereydooni, Jean Francois H. Geschwind, Michal Kulon, Lynn Jeanette Savic, Nariman Nezami, Johanna M. M. van Breugel, Fabian Laage-Gaupp, MingDe Lin, Julius Chapiro, Todd Schlachter, Milena Miszczuk, Tamara Wahlin, Vinayak Thakur, Bruno R Tegel, Eliot Funai
المصدر: Translational Oncology, Vol 13, Iss 3, Pp-(2020)
Translational Oncology
بيانات النشر: Elsevier, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Original article, Cancer Research, Imaging biomarker, Malignancy, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, medicine, Fluorodeoxyglucose, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Exact test, 030104 developmental biology, Oncology, Positron emission tomography, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Lipiodol, business, Nuclear medicine, medicine.drug
الوصف: PURPOSE:To prospectively investigate whether Lipiodol can be used as a potential imaging biomarker of tumor response after conventional transarterial chemoembolization (cTACE) for both primary and secondary liver cancer. MATERIALS AND METHODS: This prospective single-center single-arm clinical trial enrolled a total of 39 patients with primary or secondary liver malignancy [hepatocellular carcinoma (HCC), n = 22 and non-HCC, n = 17]. Patients were treated with cTACE according to a standardized protocol and underwent multimodality imaging at baseline [magnetic resonance imaging (MRI)/computed tomography (CT)/positron emission tomography (PET)]; at 24 hours post-TACE (CT); and at 30, 90, and 180 days post-TACE (MRI/CT/PET). Image data analysis included quantitative assessment of tumor characteristics, Lipiodol deposition, fluorodeoxyglucose uptake, and tumor response assessment. Statistical analysis included linear regression, Student's t tests, Wilcoxon rank sum and signed rank test, Chi-square, and Fisher's exact test. RESULTS: Image analysis demonstrated that baseline tumor diameter (R2 = 0.4, P = .0001), area (R2 = 0.45, P
اللغة: English
تدمد: 1936-5233
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a830b0719e8f97db61d082eec64792
http://www.sciencedirect.com/science/article/pii/S1936523319304346
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....92a830b0719e8f97db61d082eec64792
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19365233