Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Measurement in Patients Who Undergo Left Ventricular Assist Device Implantation Surgery
| العنوان: | Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Measurement in Patients Who Undergo Left Ventricular Assist Device Implantation Surgery |
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| المؤلفون: | Kent Doi, Mitsutoshi Kimura, Takehiro Matsubara, Osamu Kinoshita, Takeshi Ishii, Yoshifumi Hamasaki, Eisei Noiri, Naoki Yahagi, Minoru Ono, Maki Sumida, Masaomi Nangaku |
| المصدر: | Circulation Journal. 78:1891-1899 |
| بيانات النشر: | Japanese Circulation Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Renal function, urologic and male genital diseases, Perioperative Care, Prosthesis Implantation, chemistry.chemical_compound, Postoperative Complications, Lipocalin-2, Proto-Oncogene Proteins, Internal medicine, medicine, Humans, Renal replacement therapy, Perioperative Period, Creatinine, business.industry, Central venous pressure, Acute kidney injury, General Medicine, Perioperative, Acute Kidney Injury, Middle Aged, medicine.disease, Lipocalins, female genital diseases and pregnancy complications, Surgery, Renal Replacement Therapy, chemistry, Ventricular assist device, Cardiology, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, Complication, business, Acute-Phase Proteins |
| الوصف: | Background Perioperative complication of end-organ injury including acute kidney injury (AKI) is a frequent and severe problem for patients undergoing left ventricular assist device (LVAD) implantation. This study evaluated an emerging AKI biomarker, plasma neutrophil gelatinase-associated lipocalin (NGAL), in a LVAD implantation cohort. Methods and results Of 31 LVAD implantation patients enrolled to this study, 17 (55%) patients were diagnosed as having AKI. Six AKI patients showed severe AKI requiring renal replacement therapy (RRT). Plasma NGAL values in the AKI-with-RRT group (n=6) were significantly higher than that in other patients, although the AKI-without-RRT (n=11) group showed a similar level of plasma NGAL to that of the non-AKI group (n=14). Multiple logistic regression analysis revealed that plasma NGAL measured at pre-operation and central venous pressure at pre-operation and 12 h after surgery independently discriminated against postoperative RRT requirement. In the AKI-with-RRT group, plasma NGAL decreased before termination of RRT in 4 patients who eventually showed renal recovery, although no decline of plasma NGAL was observed in 2 patients who showed no recovery of renal function. Removal of blood NGAL by continuous hemodiafiltration was shown to be 70-75% lower than that of creatinine. Conclusions Measurement of perioperative plasma NGAL is useful for predicting severe AKI requiring RRT and renal recovery in patients who have had LVAD implantation surgery. Further investigation is necessary to confirm these findings because this study examined a low number of patients. |
| تدمد: | 1347-4820 1346-9843 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9494d8f1e751d58c86d811882c85ffd0 https://doi.org/10.1253/circj.cj-14-0008 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9494d8f1e751d58c86d811882c85ffd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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