Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes
العنوان: | Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes |
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المؤلفون: | Carolina R. Melo-Silva, Marisa I. Roman, Cory J. Knudson, Lingjuan Tang, Ren-Huan Xu, Michel Tassetto, Patrick Dolan, Raul Andino, Luis J. Sigal |
المصدر: | Cell reports. 41(8) |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Mice, Ectromelia virus, Poxviridae, Interferon Type I, Animals, Ectromelia, Infectious, Antiviral Agents, General Biochemistry, Genetics and Molecular Biology, Monocytes |
الوصف: | Inflammatory monocytes (iMOs) and B cells are the main targets of the poxvirus ectromelia virus (ECTV) in the lymph nodes of mice and play distinct roles in surviving the infection. Infected and bystander iMOs control ECTV's systemic spread, preventing early death, while B cells make antibodies that eliminate ECTV. Our work demonstrates that within an infected animal that survives ECTV infection, intrinsic and bystander infection of iMOs and B cells differentially control the transcription of genes important for immune cell function and, perhaps, cell identity. Bystander cells upregulate metabolism, antigen presentation, and interferon-stimulated genes. Infected cells downregulate many cell-type-specific genes and upregulate transcripts typical of non-immune cells. Bystander (Bys) and infected (Inf) iMOs non-redundantly contribute to the cytokine milieu and the interferon response. Furthermore, we uncover how type I interferon (IFN-I) or IFN-γ signaling differentially regulates immune pathways in Inf and Bys iMOs and that, at steady state, IFN-I primes iMOs for rapid IFN-I production and antigen presentation. |
تدمد: | 2211-1247 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95490a0e847f8b522f9be50e2d48d6b3 https://pubmed.ncbi.nlm.nih.gov/36417857 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....95490a0e847f8b522f9be50e2d48d6b3 |
قاعدة البيانات: | OpenAIRE |
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