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Effect of Withania somnifera hydroalcoholic extract and other dietary interventions in improving muscle strength in aging rats

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العنوان: Effect of Withania somnifera hydroalcoholic extract and other dietary interventions in improving muscle strength in aging rats
المؤلفون: Sneha Singh, Vandana Panda, S Sudhamani, Asawari Hare, Amol Deshmukh, Lal Hingorani
المصدر: Journal of Ayurveda and Integrative Medicine, Vol 12, Iss 4, Pp 623-632 (2021)
Journal of Ayurveda and Integrative Medicine
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: AMPK, medicine.medical_specialty, Aging muscle, Antioxidant, medicine.medical_treatment, Withania somnifera, medicine.disease_cause, Grip strength, chemistry.chemical_compound, Internal medicine, Drug Discovery, medicine, Miscellaneous systems and treatments, biology, business.industry, Protein, RZ409.7-999, Skeletal muscle, Muscle weakness, Malondialdehyde, biology.organism_classification, Resistance exercise, medicine.anatomical_structure, Endocrinology, Complementary and alternative medicine, chemistry, Bcl-2 and bax, Original Research Article (Experimental), medicine.symptom, business, Oxidative stress
الوصف: Background Aging leads to loss of skeletal muscle, diminished muscle strength, and decline in physical functions. Objective This study evaluates Withania somnifera and some dietary interventions to combat muscle weakness in aging rats. Materials and methods Rats (12–13 months old) corresponding to a human age of 60–65 years were assigned to various groups and given orally a standardized W. somnifera extract (WSE, 500 mg/kg) or a protein cocktail comprising soybean (1.5 g/kg) and quinoa (1 g/kg) or a combination of WSE and the protein cocktail or whey protein (1 g/kg) as a reference standard or only resistance exercise for 60 days. Grip strength and blood glucose levels were monitored weekly. At the end of the treatment, total protein, inflammatory markers (CRP, IL-6 and TNF-α), AMPK, malondialdehyde, glutathione, antioxidant enzymes and apoptotic regulator genes (Bax and Bcl-2) were assayed. The biceps brachii muscle of all animals was subjected to histomorphological study. Results All treatments successfully attenuated aging-elevated glucose, CRP, IL-6, TNF-α, AMPK, malondialdehyde, and Bax levels. A significant restoration of the aging-depleted total protein levels, glutathione, superoxide dismutase, catalase, and Bcl-2 was noted in the treatment groups. An increase in grip strength and greater biceps mass with all treatments indicated regaining of the frail aging muscle's strength and functionality. The WSE + protein treatment elicited the best results among all treatment groups to optimize muscle strength. Conclusion All the interventions curbed muscle loss and strengthened the skeletal muscle by reducing inflammation, oxidative stress and apoptosis, and increasing ATP availability to the muscle.
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اللغة: English
تدمد: 0975-9476
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9955db77aaa2f628ec4271d297784cd6
http://www.sciencedirect.com/science/article/pii/S0975947621001091
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9955db77aaa2f628ec4271d297784cd6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09759476