Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax
| العنوان: | Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax |
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| المؤلفون: | Frederick Annang, Khalid S. Al Maqbali, Fernando Reyes, Jioji N. Tabudravu, Emmanuel Tope Oluwabusola, Marcel Jaspars, Guiomar Pérez-Moreno |
| المساهمون: | Fundación MEDINA, European Commission |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Chagas disease, F163, Antiparasitic, medicine.drug_class, Stereochemistry, Dimer, Trypanosoma cruzi, Plasmodium falciparum, malaria, Antiprotozoal Agents, Bioengineering, Biochemistry, sponge, chemistry.chemical_compound, psammaplin, Alkaloids, Biosynthesis, Parasitic Sensitivity Tests, parasitic diseases, medicine, Animals, Aplysinella rhax, Molecular Biology, Biological Products, biology, Molecular Structure, General Chemistry, General Medicine, biology.organism_classification, Malaria, Porifera, Sponge, chemistry, bromotyrosine, Bromotyrosine, Molecular Medicine, Tyrosine, Two-dimensional nuclear magnetic resonance spectroscopy, Salicylic acid |
| الوصف: | Ten bromotyrosine alkaloids were isolated and characterised from the marine sponge Aplysinella rhax (de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P and two other analogues, psammaplin O and 3-bromo-2-hydroxy-5-(methoxycarbonyl)benzoic acid, which have not been previously reported from natural sources. HR-ESI-MS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC at 19±5 and 29±6 μM against Trypanzoma cruzi Tulahuen C4, and the lethal human malaria species Plasmodium falciparum clone 3D7, respectively, while psammaplins A and D exhibited low activity against both parasites. This is the first report of the antimalarial and antitrypanosomal activity of the psammaplin-type compounds. Additionally, the biosynthesis hypotheses of three natural products were proposed. E.O.and J.T. wish to thank Mr. Russell Gray of Marine Biodiscovery Centre, Aberdeen and Jesús Martín of Fundación Medina for NM R and mass spectrometry analysis, respectively.This work was partially sup-ported by the European Union Erasmus+Programme providing a mobility grant for E.O.to Granada,Spain.J.T. wishes to thank the resource owners of the districtof Wainunu, Bua,Fiji Islands,for the marine sponge used in this study. M.J. wishes to thank the EU Seventh Framework Programme Project Pharma Sea (grant agreement No. 312184 )for financial support and F.R wishes to thank Fundación MEDINA,Granada,Spain,for financia lsupport |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1612-1872 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8b82db31ecdf466b9b7b44805d4edd |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9a8b82db31ecdf466b9b7b44805d4edd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16121872 |
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