The presence of Prevotella melaninogenica within tissue and preliminary study on its role in the pathogenesis of oral lichen planus
| العنوان: | The presence of Prevotella melaninogenica within tissue and preliminary study on its role in the pathogenesis of oral lichen planus |
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| المؤلفون: | Yi‐ting Guo, Saiwei Zheng, Liting Cai, Pan Xu, Zheng‐wu Tan, Yuan He, Ruixin Zhu |
| المصدر: | Oral Diseases. 28:1580-1590 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Prevotella melaninogenica, Proinflammatory cytokine, Pathogenesis, Mice, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, medicine, Animals, Oral mucosa, General Dentistry, In Situ Hybridization, Fluorescence, Lamina propria, medicine.diagnostic_test, business.industry, Mouth Mucosa, 030206 dentistry, medicine.disease, Epithelium, stomatognathic diseases, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Cytokines, Oral lichen planus, business, Lichen Planus, Oral, Fluorescence in situ hybridization |
| الوصف: | OBJECTIVE Oral lichen planus (OLP) is a chronic inflammatory disease that occurs in the oral mucosa with characteristic white striations lesions, recurrent erosions, and pains. The etiology and pathogenesis of OLP are still unclear. MATERIALS AND METHODS We analyzed the bacterial community structure of buccal mucosa in patients with OLP and normal controls by high-throughput sequencing. Fluorescence in situ hybridization (FISH) was used to detect Prevotella melaninogenica (P. melaninogenica) in 13 OLP samples and 10 controls. The amounts of P. melaninogenica in OLP buccal mucosa and the expression of inflammatory cytokines in co-culture of mouse-derived macrophages with P. melaninogenica were detected by RT-qPCR. RESULTS The P. melaninogenica was more abundant in OLP than in healthy controls, and the differences were significant at the level of the phylum, family, genus, and species (p |
| تدمد: | 1601-0825 1354-523X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7fcee37542f611d77b15383c25ffff https://doi.org/10.1111/odi.13862 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9c7fcee37542f611d77b15383c25ffff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16010825 1354523X |
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