Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion
| العنوان: | Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion |
|---|---|
| المؤلفون: | Makoto Mark Taketo, Norbert B. Ghyselinck, Marie-Christine Chaboissier, Maxime Jourden, Morgane Le Rolle, Anne Amandine Chassot |
| المساهمون: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Kyoto University [Kyoto], Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Kyoto University, CHASSOT, Anne Amandine |
| المصدر: | Developmental Biology Developmental Biology, 2017, 426 (1), pp.17-27. ⟨10.1016/j.ydbio.2017.04.010⟩ |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Canonical WNT signalling, endocrine system, [SDV]Life Sciences [q-bio], Proliferation, Apoptosis, Mice, Transgenic, Gonocytes, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Gonocyte, Spermatocytes, Testis, Animals, CTNNB1, Progenitor cell, Spermatogenesis, RSPO1, Wnt Signaling Pathway, Molecular Biology, beta Catenin, Cell Proliferation, Adult Germline Stem Cells, Wnt signaling pathway, Cell Differentiation, Cell Biology, Spermatogonia, Hedgehog signaling pathway, Cell biology, Enzyme Activation, Mice, Inbred C57BL, [SDV] Life Sciences [q-bio], 030104 developmental biology, Immunology, Germ line development, Stem cell, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | International audience; The differentiation of germ cells into oogonia or spermatogonia is the first step that eventually gives rise to fully mature gametes. In the female fetal gonad, the RSPO1/WNT/CTNNB1 signalling pathway is involved in primordial germ cell proliferation and differentiation into female germ cells, which are able to enter meiosis. In the postnatal testis, the WNT/CTNNB1 pathway also mediates proliferation of spermatogonial stem cells and progenitor cells. Here we show that forced activation of the WNT/CTNNB1 pathway in fetal gonocytes using transgenic mice leads to deregulated spermatogonial proliferation, and exhaustion of the spermatocytes by apoptosis, resulting in a hypoplastic testis. These findings demonstrate that a finely tuned timing in WNT/CTNNB1 signalling activity is required for spermatogenesis. |
| تدمد: | 0012-1606 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb9eb360ebb4ebe15ed0aba364aaedf https://doi.org/10.1016/j.ydbio.2017.04.010 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9cb9eb360ebb4ebe15ed0aba364aaedf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00121606 |
|---|