The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
| العنوان: | The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study |
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| المؤلفون: | Tom R. Hill, Carol Jagger, Carmen Ruiz-Martin, Rachel Duncan, Sarah Hakeem, Terry J. Aspray, Nuno Mendonça, John C. Mathers, Andrew Kingston |
| المصدر: | Nutrients, Vol 12, Iss 2742, p 2742 (2020) Nutrients Volume 12 Issue 9 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Activities of daily living, Physical activity, Nutritional Status, 030209 endocrinology & metabolism, lcsh:TX341-641, Article, 03 medical and health sciences, Disability Evaluation, 0302 clinical medicine, Activities of Daily Living, medicine, Vitamin D and neurology, Cognitive status, Humans, 030212 general & internal medicine, Vitamin D, Association (psychology), Severe disability, Geriatric Assessment, Aged, 80 and over, Nutrition and Dietetics, business.industry, Vitamin D Deficiency, vitamin D status, disability, Vitamin D supplement, Female, business, lcsh:Nutrition. Foods and food supply, Food Science, very old adults |
| الوصف: | Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an &lsquo adequate&rsquo 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of < 25 nmol/L, 25&ndash 50 nmol/L and > 50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations < 25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcd0b2435dbc7922e38db4539e9c860 https://www.mdpi.com/2072-6643/12/9/2742 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9dcd0b2435dbc7922e38db4539e9c860 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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