Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells
العنوان: | Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells |
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المؤلفون: | Eileen Smith, Jennifer R. Shingleton, Sandeep S. Dave, Jie Wang, Razvan Panea, Qiu Qin, Cassandra Love, Othmane Jadi, Nicholas S. Davis, Rachel Kositsky, Lanie Happ, Carolyn H. Baloh, Anupama Reddy, Naina Singhi, Devang Thakkar, Tushar Dave, Xiang Li |
المصدر: | Cold Spring Harb Perspect Med |
بيانات النشر: | Cold Spring Harbor Laboratory Press, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | 0301 basic medicine, B-Lymphocytes, Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Treatment options, Classification scheme, Computational biology, Biology, medicine.disease, World Health Organization, General Biochemistry, Genetics and Molecular Biology, Lymphoma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, medicine, Humans, Who classification, Perspectives |
الوصف: | Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-origin and molecular phenotypes. We review how lymphomas arise throughout the B-cell development process as well as the molecular and clinical features of prominent B-cell lymphomas. We provide an overview of the major progress that has occurred over the past decade in terms of our molecular understanding of these diseases. We discuss treatment options available and focus on a number of the diverse research tools that have been employed to improve our understanding of these diseases. We discuss the problem of heterogeneity in lymphomas and anticipate that the near future will bring significant advances that provide a measurable impact on NHL outcomes. |
اللغة: | English |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3788f0f1a1ba7ed697a229096793c6 https://europepmc.org/articles/PMC7919396/ |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....9f3788f0f1a1ba7ed697a229096793c6 |
قاعدة البيانات: | OpenAIRE |
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