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Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries

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العنوان: Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries
المؤلفون: Krisztina László, Jun Zhang, Mika Gissler, Yongfu Yu, Hui Wang, Fei Li, Jiong Li
المصدر: European Journal of Epidemiology
Wang, H, László, K D, Gissler, M, Li, F, Zhang, J, Yu, Y & Li, J 2021, ' Maternal hypertensive disorders and neurodevelopmental disorders in offspring : a population-based cohort in two Nordic countries ', European Journal of Epidemiology, vol. 36, no. 5, pp. 519-530 . https://doi.org/10.1007/s10654-021-00756-2
سنة النشر: 2020
مصطلحات موضوعية: Gestational hypertension, Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Offspring, Pre-Eclampsia/epidemiology, Intellectual disability, Register-based research, Cohort Studies, Prenatal Exposure Delayed Effects/epidemiology, Pre-Eclampsia, Pregnancy, Risk Factors, mental disorders, medicine, Attention deficit hyperactivity disorder, Humans, Perinatal Epidemiology, Intellectual Disability/epidemiology, Attention Deficit Disorder with Hyperactivity/epidemiology, Sibling, Autism spectrum disorder, Hypertensive disorders during pregnancy, Sweden, business.industry, Hazard ratio, Infant, Newborn, Infant, Neurodevelopmental Disorders/epidemiology, Hypertension, Pregnancy-Induced, medicine.disease, Sweden/epidemiology, Attention-deficit/hyperactivity disorder, Attention Deficit Disorder with Hyperactivity, Neurodevelopmental Disorders, Child, Preschool, Prenatal Exposure Delayed Effects, Female, Hypertension, Pregnancy-Induced/epidemiology, business, Pre-eclampsia
الوصف: Maternal hypertensive disorders during pregnancy (HDP) have been associated with neuropsychiatric problems in offspring. We aim to investigate the associations between specific types of maternal HDP and offspring neurodevelopmental disorders and further examine whether the timing of onset and severity of HDP would affect these associations. The study population consisted of 4,489,044 live-born singletons in Denmark during 1978–2012 and Sweden during 1987–2010. Maternal HDP was categorized into chronic hypertension, gestational hypertension, and pre-eclampsia; pre-eclampsia was further stratified according to timing (early-onset, late-onset), or severity (moderate, severe) of the disease. Neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID), were defined by ICD-coded register diagnosis. Cox regression was used to calculate hazard ratios (HR) while adjusting for potential confounders, and sibling analyses assessed the influence of unmeasured shared familial factors. Maternal HDP was associated with increased risks of ADHD (HR, 1.24; 95% confidence interval [CI], 1.20–1.28), ASD (1.29 [1.24–1.34]), and ID (1.58 [1.50–1.66]) in offspring, respectively, which was mostly driven by pre-eclampsia. The strongest associations were observed for early-onset and severe pre-eclampsia, and the corresponding HRs for ADHD, ASD and ID were 1.93 [1.73–2.16], 1.86 [1.61–2.15], and 3.99 [3.42–4.65], respectively. The results were similar in the sibling analyses. The associations between maternal HDP and offspring neurodevelopmental disorders were consistent across the subgroups of sex, preterm status, parity, maternal age and psychiatric disorders. Maternal HDP, especially early-onset pre-eclampsia, are associated with increased risks of ADHD, ASD, and ID in particular, independent of shared familial factors. Supplementary Information The online version contains supplementary material available at 10.1007/s10654-021-00756-2.
وصف الملف: application/pdf
تدمد: 1573-7284
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f398ae0ab4b32347fcf56c545333dcf
https://pubmed.ncbi.nlm.nih.gov/33948753
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9f398ae0ab4b32347fcf56c545333dcf
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15737284