Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN
| العنوان: | Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN |
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| المؤلفون: | Paediatric IBD Porto Group of ESPGHAN, Joosse, M E, Aardoom, M A, Kemos, P, Turner, D, Wilson, D C, Koletzko, S, Martin-de-Carpi, J, Fagerberg, U L, Spray, C, Tzivinikos, C, Sladek, M, Shaoul, R, Roma-Giannikou, E, Bronsky, J, Serban, D E, Ruemmele, F M, Garnier-Lengline, H, Veres, G, Hojsak, I, Kolho, K L, Davies, I H, Aloi, M, Lionetti, P, Hussey, S, Veereman, G, Braegger, C P, Trindade, E, Wewer, A V, Hauer, A C, de Vries, A C H, Sigall Boneh, R, Sarbagili Shabat, C, Levine, A, de Ridder, L |
| المساهمون: | Faculty of Sciences and Bioengineering Sciences, Clinical sciences, Growth and Development, Art Sciences and Archaeology, Faculty of Psychology and Educational Sciences, Clinicum, Children's Hospital, Lastentautien yksikkö, University of Helsinki, HUS Children and Adolescents, Gastroenterology & Hepatology, Pediatrics |
| المصدر: | ALIMENTARY PHARMACOLOGY & THERAPEUTICS r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Alimentary Pharmacology & Therapeutics, 48(5), 523-537. Wiley-Blackwell Publishing Ltd |
| بيانات النشر: | Wiley-Blackwell Publishing Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Colorectal cancer, CHILDREN, T-CELL LYMPHOMA, THERAPY, Inflammatory bowel disease, COLORECTAL-CANCER, 0302 clinical medicine, Risk Factors, Neoplasms, SWEDEN, T-cell lymphoma, Pharmacology (medical), Prospective Studies, Age of Onset, Young adult, Child, Cause of death, RISK, Gastroenterology, CROHNS-DISEASE, PREVALENCE, 3. Good health, THIOPURINES, Europe, 317 Pharmacy, Child, Preschool, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, Adolescent, Malignancy, Risk Assessment, Primary sclerosing cholangitis, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, METAANALYSIS, Hepatology, business.industry, ibd, Infant, Newborn, Infant, Cancer, Inflammatory Bowel Diseases, medicine.disease, digestive system diseases, 3121 General medicine, internal medicine and other clinical medicine, business |
| الوصف: | Background: Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those of treatments. Malignancy and mortality in IBD have been associated with disease-related inflammation and immune suppression, but data are limited due to their rare occurrence. Aim: To identify and describe the most common causes of mortality, types of cancer and previous or current therapy among children and young adults with paediatric-onset IBD. Methods: Information on paediatric-onset IBD patients diagnosed with malignancy or mortality was prospectively collected via a survey in 25 countries over a 42-month period. Patients were included if death or malignancy occurred after IBD diagnosis but before the age of 26years. Results: In total, 60 patients were identified including 43 malignancies and 26 fatal cases (9 due to cancer). Main causes of fatality were malignancies (n=9), IBD or IBD-therapy related nonmalignant causes (n=10; including 5 infections), and suicides (n=3). Three cases, all fatal, of hepatosplenic T-cell lymphoma were identified, all were biologic-naive but thiopurine-exposed. No other haematological malignancies were fatal. The 6 other fatal cancer cases included 3 colorectal adenocarcinomas and 3 cholangiocarcinomas (CCAs). Primary sclerosing cholangitis (PSC) was present in 5 (56%) fatal cancers (1 colorectal carcinoma, 3 CCAs and 1 hepatosplenic T-cell lymphoma). Conclusions: We report the largest number of paediatric-onset IBD patients with cancer and/or fatal outcomes to date. Malignancies followed by infections were the major causes of mortality. We identified PSC as a significant risk factor for cancer-associated mortality. Disease-related adenocarcinomas were a commoner cause of death than lymphomas. |
| تدمد: | 1365-2036 0269-2813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a334ca65bb9a1aa30e5472a381e5ff57 https://doi.org/10.1111/apt.14893 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a334ca65bb9a1aa30e5472a381e5ff57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652036 02692813 |
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