Recoding a cocaine-place memory engram to a neutral engram in the hippocampus
| العنوان: | Recoding a cocaine-place memory engram to a neutral engram in the hippocampus |
|---|---|
| المؤلفون: | S. Lucas Black, Pavel V Perestenko, Leon G. Reijmers, Natalia Campo-Urriza, Gido M. van de Ven, Colin G. McNamara, Claire T Bratley, Stéphanie Trouche, David Dupret |
| المصدر: | Nature neuroscience |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Action Potentials, Hippocampus, Mice, Transgenic, Engram, Optogenetics, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Cocaine, Memory, Conditioning, Psychological, Animals, Place memory, General Neuroscience, fungi, Neurophysiology, Mice transgenic, Mice, Inbred C57BL, 030104 developmental biology, nervous system, bacteria, Psychology, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior. |
| اللغة: | English |
| تدمد: | 1546-1726 1097-6256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cd3c5c1a3f09d8050b56a36473436a http://ora.ox.ac.uk/objects/uuid:c804d444-6dc6-4afd-8b6d-153b4c800b9f |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a4cd3c5c1a3f09d8050b56a36473436a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461726 10976256 |
|---|