Association between BRAF V600E and NRAS Q61R mutations and clinicopathologic characteristics, risk factors and clinical outcome of primary invasive cutaneous melanoma
| العنوان: | Association between BRAF V600E and NRAS Q61R mutations and clinicopathologic characteristics, risk factors and clinical outcome of primary invasive cutaneous melanoma |
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| المؤلفون: | Jiali Han, Abrar A. Qureshi, Shaowei Wu, Helen Kuo, Wen-Qing Li, Alvaro Laga Canales |
| المصدر: | Cancer Causes & Control. 25:1379-1386 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Proto-Oncogene Proteins B-raf, Oncology, Neuroblastoma RAS viral oncogene homolog, Cancer Research, medicine.medical_specialty, Pathology, Skin Neoplasms, Ultraviolet Rays, Article, GTP Phosphohydrolases, Risk Factors, Internal medicine, Epidemiology, Odds Ratio, medicine, Humans, Prospective Studies, Prospective cohort study, Melanoma, neoplasms, Survival rate, Aged, Aged, 80 and over, business.industry, Membrane Proteins, Environmental Exposure, Environmental exposure, Odds ratio, Middle Aged, Prognosis, medicine.disease, Survival Rate, Treatment Outcome, Mutation, Cutaneous melanoma, Female, business, Follow-Up Studies |
| الوصف: | Purpose Previous studies suggest that solar UV exposure in early life is predictive of cutaneous melanoma risk in adulthood, whereas the relation of BRAF mutation with sun exposure and disease prognosis has been less certain. We investigated the associations between BRAF V600E and NRAS Q61R mutations and known risk factors, clinicopathologic characteristics and clinical outcomes of melanoma in a case series of primary invasive cutaneous melanoma from the Nurses’ Health Study (NHS). Methods Somatic BRAF V600E and NRAS Q61R mutations of 127 primary invasive melanomas from the NHS cohort were determined by pyrosequencing using formalin-fixed, paraffin-embedded block tissues. Logistic regression analyses were performed to detect the associations of mutations with melanoma risk factors, and Kaplan–Meier method was used to examine associations between mutations and survival. Results The odds ratios for harboring BRAF V600E mutations were 5.54 (95 % CI 1.19–25.8, ptrend = 0.02) for women residing in states with UV index C 7 versus those residing in states with UV index B5 at 30 years of age. Patients with BRAF V600E mutations tended to have shorter melanoma-specific survival when compared to patients with wild type at both loci (median survival time 110 vs. 159 months) (p = 0.03). No association was found between NRASQ61R mutation and melanoma risk factors or melanoma-specific survival. Conclusions BRAF V600E mutations in primary cutaneous melanomas were associated with residence in locations with medium and high UV indices in mid-life. BRAF V600E mutation may be associated with an unfavorable prognosis among melanoma patients. |
| تدمد: | 1573-7225 0957-5243 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50c32174e6f44c08cc332c4a35cdfd3 https://doi.org/10.1007/s10552-014-0443-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a50c32174e6f44c08cc332c4a35cdfd3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737225 09575243 |
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