The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome
| العنوان: | The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome |
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| المؤلفون: | Ling Zhang, Meng-Xin Huang, Dan-Yan Li, Yun-Zhan Zhang, Shao-Yang Lan, Qi Luo, Yun-Kai Dai, Yun-Bo Wu, Jin-Tong Ye, Wei-Jing Chen, Ru-Liu Li, Ling Hu |
| المصدر: | Evidence-Based Complementary and Alternative Medicine. 2022:1-13 |
| بيانات النشر: | Hindawi Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Article Subject, Complementary and alternative medicine |
| الوصف: | Aims. The study aims to explore the effects of the single-nucleotide polymorphism of miR-27a and its expression in Helicobacter pylori (H. pylori)-related diseases and the relationship between gastric pathology and traditional Chinese medicine (TCM). Methods. Subjects were classified into six histopathological groups and five TCM syndrome groups. All specimens underwent H. pylori detection through rapid urease test and methylene blue staining. Histopathological characteristics were observed by hematoxylin-eosin. The expression of miR-27a and its genotype were, respectively, detected by Quantitative Real-Time PCR and direct sequencing. Results. H. pylori promoted the malignant evolution of gastric mucosa and were involved in the formation of TCM syndrome. In H. pylori-positive patients, the frequency of miR-27a CT genotype at the rs895819 locus and its expression in the gastric cancer group were higher than those in other pathological groups. TCM syndrome had a close relationship with histopathological changes, and patients with spleen-qi deficiency syndrome had a higher risk of gastric cancer than other syndromes, regardless of H. pylori infection. Conclusion. The C allele at miR-27a rs895819 locus may be an oncogene in gastric cancer. High levels of miR-27a could play an important role in gastric malignant evolution, especially cancerization. There is a certain connection between TCM syndrome and pathological changes of the gastric mucosa to some extent, where patients with SQD syndrome had a higher risk of GC. |
| وصف الملف: | text/xhtml |
| تدمد: | 1741-4288 1741-427X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73405bb773f000b19082f94292a47a0 https://doi.org/10.1155/2022/3086205 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a73405bb773f000b19082f94292a47a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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