Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration
| العنوان: | Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration |
|---|---|
| المؤلفون: | Wim Jiskoot, M. Reza Nejadnik, Inas El Bialy |
| المصدر: | PHARMACEUTICAL RESEARCH, 34(6), 1152-1170 PHARMACEUTICAL RESEARCH Pharmaceutical Research |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Bone Regeneration, animal structures, Polymers, Drug Compounding, Pharmaceutical Science, 02 engineering and technology, Bioinformatics, Bone morphogenetic protein, Regenerative medicine, 03 medical and health sciences, Drug Delivery Systems, Protein stability, Drug Stability, Bone morphogenetic proteins, Protein formulation, Animals, Humans, Medicine, Effective treatment, Pharmacology (medical), Bone formation, Bone regeneration, Pharmacology, Tissue Engineering, Tissue Scaffolds, business.industry, Organic Chemistry, Growth factor, 021001 nanoscience & nanotechnology, Biotechnology, Drug Liberation, 030104 developmental biology, embryonic structures, Molecular Medicine, Delivery system, Expert Review, 0210 nano-technology, business, Site of action, Signal Transduction |
| الوصف: | Bone morphogenetic proteins (BMPs) are responsible for bone formation during embryogenesis and bone regeneration and remodeling. The osteoinductive action of BMPs, especially BMP-2 and BMP-7, has led to their use in a range of insurmountable treatments where intervention is required for effective bone regeneration. Introduction of BMP products to the market, however, was not without reports of multiple complications and side effects. Aiming for optimization of the therapeutic efficacy and safety, efforts have been focused on improving the delivery of BMPs to lower the administered dose, localize the protein, and prolong its retention time at the site of action. A major challenge with these efforts is that the protein stability should be maintained. With this review we attempt to shed light on how the stability of BMPs can be affected in the formulation and delivery processes. We first provide a short overview of the current standing of the complications experienced with BMP products. We then discuss the different delivery parameters studied in association with BMPs, and their influence on the efficacy and safety of BMP treatments. In particular, the literature addressing the stability of BMPs and their possible interactions with components of the delivery system as well as their sensitivity to conditions of the formulation process is reviewed. In summary, recent developments in the fields of bioengineering and biopharmaceuticals suggest that a good understanding of the relationship between the formulation/delivery conditions and the stability of growth factors such as BMPs is a prerequisite for a safe and effective treatment. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e7533554e54df502657edc7842aea http://hdl.handle.net/1887/54672 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a75e7533554e54df502657edc7842aea |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |