Benzazetidines and Related Compounds: Synthesis and Potential
| العنوان: | Benzazetidines and Related Compounds: Synthesis and Potential |
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| المؤلفون: | Marco Bella, Simone Placidi, Riccardo Salvio |
| المصدر: | Chemistry – A European Journal. 26:10157-10174 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | azetidines, cyclization reactions, N-heterocycles, organocatalysis, ring strain, cyclization, 010405 organic chemistry, Chemistry, Organic Chemistry, N-heterocycles, ring strain, azetidine, cyclization, organocatalysis, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, Settore CHIM/06, 0104 chemical sciences, Biochemical engineering, azetidine, Amination |
| الوصف: | Benzazetidines are a class of N-heterocycles potentially very interesting for a variety of purposes, including biological applications and drug design. In the past, their high ring strain has hampered the development of trustable, general, and efficient synthetic methodologies for their preparation. In this review article, the aim is to disclose all the literature contributions about the synthesis of these compounds and the study of their reactivity, from the early examples to the most recent synthetic approaches. Recently, there has been a growth of interest for this heterocycle, driven by the publication of novel synthetic methodologies based on palladium-catalyzed intramolecular C-H amination and organocatalyzed ring-closure of 2-(N-Boc-anilino)-α-ketoesters/amides. |
| تدمد: | 1521-3765 0947-6539 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f143eb6912ea4e7b023cfa85c20da1 https://doi.org/10.1002/chem.201905668 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a7f143eb6912ea4e7b023cfa85c20da1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213765 09476539 |
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