Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation, and gut microbiome of high-fat diet-fed mice
| العنوان: | Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation, and gut microbiome of high-fat diet-fed mice |
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| المؤلفون: | Matthias Van Hul, Amandine Everard, Massimo Marzorati, Nathalie M. Delzenne, Pieter Van den Abbeele, Kavita Karnik, Mervyn De Souza, Kirstie Canene-Adams, Patrice D. Cani |
| المساهمون: | UCL - SSS/LDRI - Louvain Drug Research Institute |
| المصدر: | American journal of physiology. Endocrinology and metabolism, Vol. 319, no. 4, p. E779-E791 (2020) AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM |
| بيانات النشر: | American Physiological Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Dietary Fiber, Male, Agriculture and Food Sciences, 0301 basic medicine, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, RESISTANT STARCH, Oligosaccharides, Adipose tissue, Gut flora, Mice, 0302 clinical medicine, Resistant starch, chemistry.chemical_classification, biology, INSULIN SENSITIVITY, Chemistry, Dietary fibers, ADIPOSE-TISSUE, Body Composition, 030211 gastroenterology & hepatology, HEALTH, medicine.medical_specialty, food.ingredient, GREENGENES, Normal diet, IMPROVEMENT, PREBIOTICS, Gut microbiota, Diet, High-Fat, Zea mays, CONTRIBUTES, Excretion, 03 medical and health sciences, food, INTESTINAL MICROBIOTA, Physiology (medical), Internal medicine, medicine, Animals, Obesity, Inflammation, Probiotics, Prebiotic, Body Weight, Fatty acid, Metabolism, biology.organism_classification, Gastrointestinal Microbiome, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Insulin Resistance, Energy Metabolism |
| الوصف: | Dietary fibers are essential components of a balanced diet and have beneficial effects on metabolic functions. To gain insight into their impact on host physiology and gut microbiota, we performed a direct comparison of two specific prebiotic fibers in mice. During an 8-wk follow up, mice fed a high-fat diet (HFD) were compared with mice on a normal diet (basal condition, controls) and to mice fed the HFD but treated with one of the following prebiotics: fructooligosaccharides (FOS) or soluble corn fiber (SCF). Both prebiotic fibers led to a similar reduction of body weight and fat mass, lower inflammation and improved metabolic parameters. However, these health benefits were the result of different actions of the fibers, as SCF impacted energy excretion, whereas FOS did not. Interestingly, both fibers had very distinct gut microbial signatures with different short-chain fatty acid profiles, indicating that they do not favor the growth of the same bacterial communities. Although the prebiotic potential of different fibers may seem physiologically equivalent, our data show that the underlying mechanisms of action are different, and this by targeting different gut microbes. Altogether, our data provide evidence that beneficial health effects of specific dietary fibers must be documented to be considered a prebiotic and that studies devoted to understanding how structures relate to specific microbiota modulation and metabolic effects are warranted. |
| وصف الملف: | application/pdf |
| تدمد: | 1522-1555 0193-1849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a809acbac14b87818423a53b5e3e8504 https://doi.org/10.1152/ajpendo.00108.2020 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a809acbac14b87818423a53b5e3e8504 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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