Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors
| العنوان: | Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors |
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| المؤلفون: | Carla Ghelardini, Antonio Giordani, Lidia Sautebin, Antonietta Rossi, S. Alfonso, Maurizio Anzini, Claudio Battilocchio, Angela Di Capua, Vincenzo Calderone, Sara Consalvi, Lorenzo Di Cesare Mannelli, Mariangela Biava, Stefano Persiani, Paola Patrignani, Milena Colovic, Melania Dovizio, Giovanna Poce, Alma Martelli, Lara Testai |
| المساهمون: | Biava, M, Battilocchio, C, Poce, G, Alfonso, S, Consalvi, S, Di Capua, A, Calderone, V, Martelli, A, Testai, L, Sautebin, Lidia, Rossi, Antonietta, Ghelardini, C, Di Cesare Mannelli, L, Giordani, A, Persiani, S, Colovic, M, Dovizio, M, Patrignani, P, Anzini, M. |
| المصدر: | Bioorganicmedicinal chemistry. 22(2) |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Clinical Biochemistry, Pharmaceutical Science, Constriction, Pathologic, Pharmacology, Carrageenan, Biochemistry, chemistry.chemical_compound, Mice, Amide, CINODs, Cyclooxygenases, Coxibs, 1,5-Diarylpyrroles, Pharmacodynamic hybrids, Nitric oxide, Drug Discovery, Moiety, Edema, Acetic Acid, coxibs, 5-diarylpyrroles, cyclooxygenases, Liver, Hyperalgesia, cinods, nitric oxide, pharmacodynamic hybrids, Molecular Medicine, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide, medicine.symptom, Glycine, Nitric Oxide, Cell Line, Structure-Activity Relationship, In vivo, medicine, Animals, Humans, Rats, Wistar, Molecular Biology, Nitrites, Nitrates, Cyclooxygenase 2 Inhibitors, CINODs, Cyclooxygenases, Coxibs, 1,5-Diarylpyrroles, Pharmacodynamic hybrids, Nitric oxide, Organic Chemistry, Amides, Rats, PyBOP, chemistry, Cyclooxygenase 2 |
| الوصف: | We report herein the development, synthesis, physicochemical and pharmacological characterization of a novel class of pharmacodynamic hybrids that selectively inhibit cyclooxygenase-2 (COX-2) isoform and present suitable nitric oxide releasing properties. The replacement of the ester moiety with the amide group gave access to in vivo more stable and active derivatives that highlighted outstanding pharmacological properties. In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema. |
| تدمد: | 1464-3391 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88d991863c4711b3c08e43ae2ec5f02 https://pubmed.ncbi.nlm.nih.gov/24373735 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a88d991863c4711b3c08e43ae2ec5f02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14643391 |
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