Novel Projections to the Cerebrospinal Fluid-Contacting Nucleus From the Subcortex and Limbic System in Rat
| العنوان: | Novel Projections to the Cerebrospinal Fluid-Contacting Nucleus From the Subcortex and Limbic System in Rat |
|---|---|
| المؤلفون: | Jia Hong, Si-Yuan Song, Lei-Lei Lu, Xiao-Meng Zhai, Cheng-Jing Shan, Jun-Li Cao, Jia-Hao Dai, Li-Cai Zhang |
| المصدر: | Frontiers in Neuroanatomy, Vol 14 (2020) Frontiers in Neuroanatomy |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Neuroscience (miscellaneous), subcortex, projection, Biology, medicine.disease_cause, lcsh:RC321-571, lcsh:QM1-695, 03 medical and health sciences, Cellular and Molecular Neuroscience, CSF-contacting nucleus, 0302 clinical medicine, Limbic system, Cerebrospinal fluid, limbic system, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Basal forebrain, Cholera toxin, lcsh:Human anatomy, Spinal cord, Preoptic area, 030104 developmental biology, medicine.anatomical_structure, nervous system, retrograde trace, Anatomy, Nucleus, Neuroscience, 030217 neurology & neurosurgery, Homeostasis |
| الوصف: | Objective: To identify the novel projections received by the cerebrospinal fluid (CSF)-contacting nucleus from the subcortex and limbic system to understand the biological functions of the nucleus. Methods: The cholera toxin subunit B (CB), a retrograde tracer, was injected into the CSF-contacting nucleus in Sprague-Dawley rats. After 7-10 days, the surviving rats were perfused, and the whole brain and spinal cord were sliced for CB immunofluorescence detection. The CB-positive neurons in the subcortex and limbic system were observed under a fluorescence microscope, followed by 3D reconstructed with the imaris software. Results: CB-positive neurons were found in the basal forebrain, septum, periventricular organs, preoptic area, and amygdaloid structures. Five functional areas including 46 sub-regions sent projections to the CSF-contacting nucleus. However, the projections had different densities, ranging from sparse to moderate, to dense. Conclusions: According to the projections from the subcortex and limbic system, we hypothesize that the CSF-contacting nucleus participates in emotion, cognition, homeostasis regulation, visceral activity, pain, and addiction. In this study, we illustrate the novel projections from the subcortex and limbic system to the CSF-contacting nucleus, which underlies the diverse and complicated circuits of the nucleus in body regulations. |
| اللغة: | English |
| تدمد: | 1662-5129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90d15c0763b773b2a398f1fa39eaac8 https://www.frontiersin.org/article/10.3389/fnana.2020.00057/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a90d15c0763b773b2a398f1fa39eaac8 |
| قاعدة البيانات: | OpenAIRE |
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