Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes
| العنوان: | Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes |
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| المؤلفون: | Gustavo F. Gonzales |
| المصدر: | Asian Journal of Andrology. 15:368-374 |
| بيانات النشر: | Medknow, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, 17-Hydroxysteroid Dehydrogenases, Urology, men, oestradiol, Polycythemia, Review, Biology, High haemoglobin, Elevated serum, Hemoglobins, Internal medicine, medicine, Animals, Humans, Erythropoiesis, Testosterone, Androstenedione, DHEA, Hypoxia, Dehydroepiandrosterone sulphate, Serum testosterone, purl.org/pe-repo/ocde/ford#3.02.01 [https], high altitudes, Dehydroepiandrosterone Sulfate, Altitude, Testosterone (patch), General Medicine, medicine.disease, haemoglobin, Adaptation, Physiological, Endocrinology, Chronic mountain sickness, women |
| الوصف: | Populations living at high altitudes (HAs), particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis (16 g dl(-1)haemoglobin (Hb)≤21 g dl(-1)) and others with excessive erythrocytosis (EE) (Hb21 g dl(-1)). Elevated haemoglobin values (EE) are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate (DHEAS) to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity. Lower 17beta-HSD activity via Δ4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the Δ5-pathway. Currently, there are various situations in which people live (human biodiversity) with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process. |
| تدمد: | 1745-7262 1008-682X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a984976b216f5f6d8ba3be25aaa07500 https://doi.org/10.1038/aja.2012.170 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a984976b216f5f6d8ba3be25aaa07500 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17457262 1008682X |
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