Association of Drug Application and Hydration Status in Elderly Patients
| العنوان: | Association of Drug Application and Hydration Status in Elderly Patients |
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| المؤلفون: | Johannes Kraft, Laura Hoen, Andrea Raabe, Rico Zapf, Daniel Pfeffer, Stefan Kalkhof, Janosch Hildebrand |
| المساهمون: | Publica |
| المصدر: | Nutrients Nutrients, Vol 13, Iss 1929, p 1929 (2021) Volume 13 Issue 6 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Ernährung, medicine.medical_specialty, Body water, Nutritional Status, Organism Hydration Status, Clinical nutrition, malnutrition, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, prevention, Internal medicine, medicine, drug-nutrient interactions, Humans, Cognitive Dysfunction, TX341-641, nutrition assessment, 030212 general & internal medicine, Amlodipine, Aged, Geriatrics, Aged, 80 and over, body composition, Nutrition and Dietetics, geriatrics, Dehydration, business.industry, Nutrition. Foods and food supply, clinical nutrition, Furosemide, nutrition, Pharmaceutical Preparations, Bisoprolol, Geriatrie, Female, Olmesartan, business, Bioelectrical impedance analysis, Food Science, medicine.drug |
| الوصف: | Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. Mild cognitive impairment (MCI) or dementia increase the risk of dehydration and, in turn, dehydration decreases cognitive performance. The study aims to identify and assess differences in hydration status, taking into account patients’ drug treatment and diseases, using bioelectrical impedance vector analysis (BIVA), thereby revealing unfavorable aspects of prognosis. 447 geriatric patients (241 women, 206 men) including information on medication and bioelectrical impedance analysis (BIA) were investigated, which allowed studying the association between 40 drugs and the hydration status. First, patients were divided into disease groups. Renal disease and diuretic treatment were significantly different in both sexes, whereas cardiovascular patients differed exclusively for females. Next, drug enrichment was examined in either hyperhydrated or dehydrated patients. Simvastatin, candesartan, bisoprolol, amlodipine, olmesartan, furosemide, torasemide, allopurinol, mirtazapine, pantoprazole, cholecalciferol, and resveratrol showed enrichment depending on hydration status. This study demonstrated that patients can be differentiated and stratified by BIVA, taking into account medication and disease associated with hydration status. Although patients diagnosed with MCI and therefore treated with resveratrol, BIVA still showed evaluated dehydration. This is unfavorable in terms of prognosis and requires special attention. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bc25e99adba658baec4ee4e8fd42a4 http://europepmc.org/articles/PMC8226953 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a9bc25e99adba658baec4ee4e8fd42a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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