Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma
| العنوان: | Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma |
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| المؤلفون: | William Yip, Michael R. Hughes, Yicong Li, Alissa Cait, Martin Hirst, William W. Mohn, Kelly M. McNagny |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, cell fate and differentiation, Immunology, microbiome, Context (language use), Inflammation, Butyrate, Review, Biology, Cell fate determination, 03 medical and health sciences, SCFA (short chain fatty acids), 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Animals, Humans, Epigenetics, Microbiome, Lymphocytes, Mast Cells, Lung, 030304 developmental biology, HDAC inhibitor (histone deacetylase inhibitor), 0303 health sciences, epigenetics, Bacteria, medicine.disease, butyrate, Asthma, 3. Good health, Gastrointestinal Microbiome, Eosinophils, Butyrates, Phenotype, inflammation, 030220 oncology & carcinogenesis, Dysbiosis, medicine.symptom, lcsh:RC581-607, allergic asthma, Signal Transduction |
| الوصف: | The microbiome plays a fundamental role in how the immune system develops and how inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new term that highlights a crucial biological crosstalk between the intestinal microbiome and lung. A growing body of literature suggests that dysbiosis, perturbation of the gut microbiome, is a driving force behind the development, and severity of allergic asthma. Animal models have given researchers new insights into how gut microbe-derived components and metabolites, such as short-chain fatty acids (SCFAs), influence the development of asthma. While the full understanding of how SCFAs influence allergic airway disease remains obscure, a recurring theme of epigenetic regulation of gene expression in several immune cell compartments is emerging. This review will address our current understanding of how SCFAs, and specifically butyrate, orchestrates cell behavior, and epigenetic changes and will provide a detailed overview of the effects of these modifications on immune cells in the context of allergic airway disease. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa880216623a6be669b33bf16e64e2c8 http://europepmc.org/articles/PMC7917140 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aa880216623a6be669b33bf16e64e2c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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