Centriolar satellites associate with condensed chromatin in early mouse oocytes and undergo redistribution during transition to dictyate
| العنوان: | Centriolar satellites associate with condensed chromatin in early mouse oocytes and undergo redistribution during transition to dictyate |
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| المؤلفون: | Venera P. Nikolova, Pavel Rashev, Ralitsa S. Zhivkova, Maya D. Markova, Valentina P. Hadzhinesheva, Milena Mourdjeva, S. Delimitreva, Irina V. Chakarova |
| المصدر: | Biotechnology & Biotechnological Equipment, Vol 32, Iss 6, Pp 1622-1626 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, animal structures, Intracellular localization, lcsh:Biotechnology, newborn mouse ovaria, 03 medical and health sciences, lcsh:TP248.13-248.65, Cell polarity, medicine, immunofluorescence, skin and connective tissue diseases, Chemistry, urogenital system, Mammalian oocytes, PCM-1 protein, Chromatin, Cell biology, Dictyate, centriolar satellites, 030104 developmental biology, medicine.anatomical_structure, Centrosome, embryonic structures, Interphase, Centriolar satellite, Nucleus, Biotechnology |
| الوصف: | In eukaryotic cells during interphase, the centrosome is positioned close to the nucleus by a yet unidentified mechanism and determines the basic cell polarity. The aim of this study was to trace the dynamics of centriolar satellite protein PCM-1 in newborn mouse ovaria. Ovarian sections of newborn mice were subjected to immunofluorescent analysis. The intracellular localization of PCM-1 in prophase I oocytes was compared between 1- and 2-day-old mice. In oocytes from 1-day-old ovaria, double or broader single discrete PCM-1 aggregates with perinuclear localization were observed in association with condensed chromatin regions. In oocytes from 2-day-old ovaria, PCM-1 structures were less discrete and chromatin was homogenous. In some oocytes, single or double PCM-1 aggregate was still recognizable, while in others, the PCM-1-containing structure was crescent-shaped. Our study describes for the first time reorganization of centriolar satellite protein PCM-1 in prophase I oocytes from developing primordial follicles correlated with chromatin changes during transition to dictyate. |
| اللغة: | English |
| تدمد: | 1314-3530 1310-2818 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae6aae76952d0de6401fcb9f16bfe27 https://doaj.org/article/62938c9d5ad24560a9880f94307cf771 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aae6aae76952d0de6401fcb9f16bfe27 |
| قاعدة البيانات: | OpenAIRE |
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